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Recombinant Human Scavenger Receptor Class B, Member 1, Fc-His

Cat.No. : SCARB1-852H
Product Overview : A DNA sequenceencoding the mature form of human SCARB1 extracellular domain (Pro 33 - Tyr 443)was fused with a polyhistidine tag at the C-terminus.
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  • Gene Information
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Cat. No. : SCARB1-852H
Description : SCARB1 is a member of the scavenger receptorfamily. SCARB1 is expressed primarily in liver and non-placentalsteroidogenic tissues. It binds high density lipoproteins (LDL) and mediatesselective cholesterol uptake by a mechanism distinct from the LDL pathway.High density lipoproteins (HDLs) play a critical role in cholesterolmetabolism and their plasma concentrations are inversely correlated with riskfor atherosclerosis. SCARB1 is a key component in the reverse cholesteroltransport pathway and plays an important role in lipid metabolism.
Source : Human
Host : Human Cells
Form : Lyophilized from sterile PBS, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants beforelyophilization. Specific concentrations are included in the hardcopy of COA.
Purity : > 95 % as determined by SDS-PAGE
Endotoxin : ﹤1.0 EU per μgprotein as determined by the LAL method
Stability : Samplesare stable for up to twelve months from date of receipt at -70°C.
Predicted N terminal : Pro 33
Molecular Mass : The recombinanthuman SCARB1 consists of 422 amino acids and has a predicted molecular massof 48 kDa. In SDS-PAGE under reducing conditions, the apparent molecular massof rhSCARB1 is approximately 75-85 kDa due to glycosylation.
Reconstitution : A hardcopy of COAwith reconstitution instruction is sent along with the products.
Storage : Store it understerile conditions at -70°C upon receiving. Recommend to aliquot the proteininto smaller quantities for optimal storage. Avoid repeated freeze-thawcycles.
Gene Name : SCARB1 scavenger receptor class B, member 1[ Homo sapiens ]
Official Symbol : SCARB1
Synonyms : SCARB1; scavengerreceptor class B, member 1; CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; CD36 antigen (collagen type I receptor, thrombospondinreceptor)-like 1; CD36 and LIMPII analogous 1; MGC138242; OTTHUMP00000239001;OTTHUMP00000239002; OTTHUMP00000239003; OTTHUMP00000239004;OTTHUMP00000239005; OTTHUMP00000239006; scavenger receptor class Bmember 1; scavenger receptor class B type III; CD36antigen; CD36 antigen-like 1; collagen type I receptor, thrombospondinreceptor-like 1
Gene ID : 949
mRNA Refseq : NM_001082959
Protein Refseq : NP_001076428
MIM : 601040
UniProt ID : Q8WTV0
Chromosome Location : 12q24.31
Pathway : Bile secretion; Fatdigestion and absorption; Folate Metabolism; HDL-mediated lipid transport;Hepatitis C; Lipid digestion, mobilization, and transport; Lipoproteinmetabolism; metabolism; Phagosome; Selenium Pathway; Statin Pathway; VitaminA and carotenoid metabolism; Vitamin digestion and absorption
Function : 1-phosphatidylinositolbinding; apolipoprotein A-I binding; apolipoprotein binding; high-densitylipoprotein particle binding; high-density lipoprotein particle receptoractivity; lipopolysaccharide binding; lipopolysaccharide receptor activity;low-density lipoprotein particle binding; phosphatidylserinebinding; protein homodimerization activity; receptor activity;transporter activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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