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Active Recombinant Human Histone Deacetylase 6, His-tagged

Cat.No. : HDAC6-401H
Product Overview : Recombinanthuman HDAC6 was expressed in insect cells with Histag. The molecular weight of the protein is 131 kDa.
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Cat. No. : HDAC6-401H
Description : HDAC6is a class II HDAC, a group defined by its member's homology to the yeastHDAC HDA1. It is unique among human HDACs in that it contains two fulldeacetylase domains. A tubulin deacetylase, HDAC6 may act to promoteautophagic clearing of huntingtin aggregates and retard HIV1 infection, butalso to promote invasive motility in tumor cells.
Source : Producedin insect cells.
Species : Human
Supplied as : XX μg/μl in 50 mM Tris,pH 8.0, 138 mM NaCl and 10% glycerol.
Purity : > 90% bySDS-PAGE.
Molecular Weight : 131kDa (1215 aa)
Activity : > 2 U/μg.One U=1 pmol/min at 37°C, 100 μM. Active with various fluorogenic peptidesubstrates, including Fluor de Lys™ substrate and Fluor de Lys™-SIRT1.
Application : Study HDAC6kinetics and inhibitor sensitivity.
Long Term Storage : -80°C.
Storage : -70°C.The enzyme is stable on ice for the time typically required to set up anexperiment (30-60 min.), but may lose activity with prolonged storage on ice.It is recommended that thawing and dilution of the enzyme be done within asshort a time as possible before start of the assay. The remaining, unused,undiluted enzyme should be refrozen quickly by, for example, snap freezing ina dry/ice ethanol bath or liquid nitrogen. Freezing and storage of dilutedenzyme is not recommended.
Publication :
Circumvention of Gefitinib Resistance by Repurposing Flunarizine via Histone Deacetylase Inhibition (2023)
Gene Name : HDAC6 histonedeacetylase 6 [ Homo sapiens ]
Official Symbol : HDAC6
Synonyms : HDAC6;histone deacetylase 6; HD6; JM21; FLJ16239; EC 3.5.1.98; KIAA0901;OTTHUMP00000032398; OTTHUMP00000197663
Gene ID : 10013
mRNA Refseq : NM_006044
Protein Refseq : NP_006035
MIM : 300272
UniProt ID : Q9UBN7
Chromosome Location : Xp11.23
Pathway : Cell cycle; NOTCH1 Intracellular DomainRegulates Transcription; Signal Transduction; Signaling by NOTCH; Signalingby NOTCH1; Signaling events mediated by HDAC Class I; Signaling eventsmediated by HDAC Class II; TNF-alpha/NF-kB Signaling Pathway
Function : Hsp90 protein binding; NAD-dependenthistone deacetylase activity (H3-K14 specific); NAD-dependent histonedeacetylase activity (H3-K9 specific); NAD-dependent histone deacetylaseactivity (H4-K16 specific); actin binding; alpha-tubulin binding;beta-catenin binding; beta-tubulin binding; dynein complex binding; enzymebinding; histone deacetylase activity; histone deacetylase activity (H3-K16specific); histone deacetylase binding; hydrolase activity; metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can HDAC6 inhibitors be used in combination with other therapies, and if so, what synergistic effects are expected? 06/19/2022

Yes, HDAC6 inhibitors can be combined with other therapies for enhanced efficacy. Synergistic effects may include improved anti-cancer activity or neuroprotection.

Are there any ongoing clinical trials targeting HDAC6, and if so, what are the potential outcomes for patients? 05/29/2020

Yes, there are clinical trials exploring HDAC6 inhibitors as potential treatments. Positive outcomes could lead to new therapeutic options for patients.

In what other diseases has HDAC6 been implicated, and how might this knowledge be applied clinically? 12/24/2018

HDAC6 is implicated in neurodegenerative diseases and inflammatory disorders. Understanding its role could lead to novel therapeutic approaches for these conditions.

How does HDAC6 influence cellular processes, and why is this relevant in a clinical setting? 12/13/2017

HDAC6 regulates cell motility, protein trafficking, and other processes. Understanding these mechanisms is crucial for developing targeted therapies in various diseases.

Are there any known genetic variations in HDAC6, and how might these impact individual responses to treatments in a clinical setting? 08/22/2016

Genetic variations in HDAC6 may influence individual responses to treatments. Personalized medicine approaches could consider these variations for better outcomes.

Customer Reviews (3)

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Reviews
06/23/2019

    Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

    12/07/2018

      The bands of proteins in Western Blotting experiments were very clear.

      09/16/2018

        Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

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