Recombinant Human YARS protein, His-tagged
Cat.No. : | YARS-991H |
Product Overview : | Recombinant Human YARS(1-528aa) fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Tyrosyl-tRNA synthetase, also known as YARS, belongs to the class I tRNA synthetase family. YARS is essential enzyme that catalyze the aminoacylation of tRNATrp with tryptophan, an essential function of the cell"s protein synthesis machinery. Expression of YARS is highly stimulated in human cells by the addition of IFN-gamma. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl |
Molecular Mass : | 61.3 kDa (548aa) |
AA Sequence : | MGSSHHHHHH SSGLVPRGSHILFADLHAYL DNMKAPWELL ELRVSYYENV IKAMLESIGV PLEKLKFIKG TDYQLSKEYT LDVYRLSSVV TQHDSKKAGA EVVKQVEHPLLSGLLYPGLQ ALDEEYLKVD AQFGGIDQRK IFTFAEKYLP ALGYSKRVHL MNPMVPGLTG SKMSSSEEES KIDLLDRKED VKKKLKKAFCMGDAPSPEEK LHLITRNLQE VLGEEKLKEI LKERELKIYW GTATTGKPHV AYFVPMSKIA DFLKAGCEVTEPGNVENNGV LSFIKHVLFP LKSEFVILRD EKWGGNKTYT AYVDLEKDFA AEVVHPGDLK NSVEVALNKL LDPIREKFNT PALKKLASAAYPDPSKQKPM AKGPAKNSEP EEVIPSRLDI RVGKIITVEK HPDADSLYVE KIDVGEAEPR TVVSGLVQFV PKEELQDRLV VVLCNLKPQKMRGVESQGML LCASIEGINR QVEPLDPPAG SAPGEHVFVK GYEKGQPDEE LKPKKKVFEK LQADFKISEE CIAQWKQTNF MTKLGSISCKSLKGGNIS |
Purity : | >90% by SDS - PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | YARS tyrosyl-tRNA synthetase [ Homo sapiens ] |
Official Symbol : | YARS |
Synonyms : | YARS; tyrosyl-tRNA synthetase; tyrosine--tRNA ligase, cytoplasmic; tyrosine tRNA ligase 1; cytoplasmic; tyrRS; YRS; YTS; tyrosyl--tRNA ligase; tyrosine tRNA ligase 1, cytoplasmic; tyrosyl-tRNA synthetase, cytoplasmic; TYRRS; CMTDIC; |
Gene ID : | 8565 |
mRNA Refseq : | NM_003680 |
Protein Refseq : | NP_003671 |
MIM : | 603623 |
UniProt ID : | P54577 |
Chromosome Location : | 1p35.1 |
Pathway : | Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Cytosolic tRNA aminoacylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; tRNA Aminoacylation, organism-specific biosystem; |
Function : | ATP binding; interleukin-8 receptor binding; ligase activity; nucleotide binding; signal transducer activity; tRNA binding; tyrosine-tRNA ligase activity; |
Products Types
◆ Recombinant Protein | ||
YARS-10248M | Recombinant Mouse YARS Protein, His (Fc)-Avi-tagged | +Inquiry |
YARS-6279R | Recombinant Rat YARS Protein, His (Fc)-Avi-tagged | +Inquiry |
Yars-324M | Recombinant Mouse Yars Protein, MYC/DDK-tagged | +Inquiry |
YARS-1459C | Recombinant Chicken YARS | +Inquiry |
YARS-8216H | Recombinant Human YARS protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
YARS-249HCL | Recombinant Human YARS 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYARS protein can promote tumor growth and metastasis in certain types of cancer through its role in protein synthesis and cell signaling pathways.
Modifying YARS protein function through small molecules or gene therapy is being explored as a potential therapeutic strategy in disease contexts.
Certain cancer subtypes and neurological disorder patients with YARS protein dysregulation may potentially benefit from targeted therapies, pending further research.
YARS protein dysfunction has been implicated in certain neurological disorders, such as Charcot-Marie-Tooth disease and peripheral neuropathy.
Research suggests that targeting YARS protein may have therapeutic potential in certain cancer types, but further studies are needed to validate this approach.
Customer Reviews (3)
Write a reviewThe manufacturer of the YARS protein plays a vital role in supporting my trials.
the YARS protein not only fulfills my experimental requirements but is also backed by excellent technical support, which guarantees a smooth and successful research experience.
By using the YARS protein in my experiments, I am confident in obtaining accurate and dependable data.
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