Recombinant Human TLR4, GST-tagged

• Cat.No.: TLR4-292H
• Product Overview: HumanTLR4 full-length ORF (1 aa-639 aa) recombinant protein fused with GST-tag atN-terminal was expressed in wheat germ.

Specification

• Cat. No.: TLR4-292H
• Description: The protein encoded by this gene is a member of the Toll-likereceptor (TLR) family which plays a fundamental role in pathogen recognitionand activation of innate immunity. TLRs are highly conserved from Drosophilato humans and share structural and functional similarities. They recognizepathogen-associated molecular patterns (PAMPs) that are expressed oninfectious agents, and mediate the production of cytokines necessary for thedevelopment of effective immunity. The various TLRs exhibit different patternsof expression. This receptor is most abundantly expressed in placenta, and inmyelomonocytic subpopulation of the leukocytes.
• Source: wheat germ
• Form: 50mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Weight: 99.7kDa
• Purification: GlutathioneSepharose 4 Fast Flow
• Sequences of aminoacids: MPLLNLSLDLSLNPMNFIQPGAFKE IRLHKLTLRNNFDSLNVMKTCIQGL AGLEVHRLVLGEFRNEGNLEKFDKS ALEGLCNLTIEEFRLAYLDYYLDDI IDLFNCLTNVSSFSLVSVTIERVKD FSYNFGWQHLELVNCKFGQFPTLKL KSLKRLTFTSNKGGNAFSEVDLPSL EFLDLSRNGLSFKGCCSQSDFGTTS LKYLDLSFNGVITMSSNFLGLEQLE HLDFQHSNLKQMSEFSVFLSLRNLI YLDISHTHTRVAFNGIFNGLSSLEV LKMAGNSFQENFLPDIFTELRNLTF LDLSQCQLEQLSPTAFNSLSSLQVL NMSHNNFFSLDTFPYKCLNSLQVLD YSLNHIMTSKKQELQHFPSSLAFLN LTQNDFACTCEHQSFLQWIKDQRQL LVEVERMECATPSDKQGMPVLSLNI TCQMNKTIIGVSVLSVLVVSVVAVL VYKFYFHLMLLAGCIKYGRGENIYD AFVIYSSQDEDWVRNELVKNLEEGV PPFQLCLHYRDFIPGVAIAANIIHE GFHKSRKVIVVVSQHFIQSRWCIFE YEIAQTWQFLSSRAGIIFIVLQKVE KTLLRQQVELYRLLSRNTYLEWEDS VLGRHIFWRRLRKALLDGKSWNPEG TVGTGCNWQEATSI
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: TLR4 toll-like receptor 4 [ Homo sapiens]
• Official Symbol: TLR4
• Synonyms: TLR4; toll-like receptor 4; TOLL; CD284; TLR-4; ARMD10; toll-like receptor 4; hToll; homolog of Drosophila toll; CD284antigen; OTTHUMP00000022807
• Gene ID: 7099
• mRNA Refseq: NM_003266
• Protein Refseq: NP_003257
• MIM: 603030
• UniProt ID: O00206
• Chromosome Location: 9q33.1
• Pathway: Activated TLR4 signalling; Amoebiasis; IKK complex recruitmentmediated by RIP1; Immune System; Influenza A; Innate Immune System; Leishmaniasis;MyD88 cascade initiated on plasma membrane; Pathogenic Escherichia coliinfection; Pertussis; Rheumatoid arthritis; TRAF6 mediated induction of TAK1complex; Toll Like Receptor 10 (TLR10) Cascade; Toll Like Receptor 2 (TLR2)Cascade; Toll Receptor Cascades; Toll-like receptor signaling pathway
• Function: lipopolysaccharide binding; lipopolysaccharide receptor activity;phosphatidylinositol 3-kinase binding; protein binding; receptor activity; embranesignaling receptor activity