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Mouse Anti-Human CD244 Molecule, Natural Killer Cell Receptor 2B4 Monoclonal Antibody

Cat.No. : CAB11493MH
Product Overview : Mouse monoclonal antibody to human CD244 molecule, natural killer cell receptor 2B4.
  • Specification
  • Gene Information
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Antigen Description : The CD244 antigen, also known as 2B4 / CD244, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. The 2B4 / CD244 antigen identified on NK cells and T cells is capable of transmitting stimulatory signals and non-MHC-restricted killing. Reported as an activating receptor, human 2B4 / CD244 can effectively activate and enhance NK cell –mediated cytotoxicity, induce secretion of IFN-γ and matrix metalloproteinases (MMPs), as well as NK cell invasiveness. As a member of the CD2 subset of the Ig superfamily, CD244 is a high affinity ligand for CD48 and the interaction is essential for generation of NK effectors.
Specificity : Human 2B4 / SLAMF4 / CD244. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA. Human SLAMF1, Human cell lysate (293 cell line).
Immunogen : Recombinant Human 2B4 / SLAMF4 / CD244 Protein
Host : Mouse
Isotype : Mouse IgG1
Species : Human
Clone : 4G4B7
Purification : Protein A affinity chromatography
Applications : ELISA
Dilution : Direct ELISA: This antibody can be used at 0.5 - 1 μg/mL with the appropriate secondary reagents to detect Human 2B4. The detection limit for Human 2B4 is approximately 0.039 ng/well.
Preparation : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, human cell-derived, recombinant Human 2B4 / SLAMF4 / CD244. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : CD244 CD244 molecule, natural killer cell receptor 2B4 [ Homo sapiens ]
Official Symbol : CD244
Synonyms : CD244; CD244 molecule, natural killer cell receptor 2B4; CD244 natural killer cell receptor 2B4 ,natural killer cell receptor 2B4; natural killer cell receptor 2B4; 2B4; NAIL; NKR2B4; Nmrk; SLAMF4; h2B4; NK cell activation-inducing ligand; NK cell type I receptor protein 2B4; NK cell activation inducing ligand NAIL;
Gene ID : 51744
mRNA Refseq : NM_001166663
Protein Refseq : NP_001160135
MIM : 605554
UniProt ID : Q9BZW8
Chromosome Location : 1q23.1
Pathway : Cell surface interactions at the vascular wall, organism-specific biosystem; Hemostasis, organism-specific biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem;
Function : protein binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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