Rabbit Anti-Mouse CD34 Antigen Monoclonal Antibody
Cat.No. : | CAB11499RM |
Product Overview : | Rabbit monoclonal antibody to mouse Cd34 antigen. |
- Specification
- Gene Information
- Related Products
Antigen Description : | Mouse CD34 molecule is a member of a family of single-pass transmembrane sialomucin proteins, and is selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. As a monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. Although used clinically in hematopoietic stem cell transplantation for more than 15 years, little is known about the exact function of CD34. It may act as an adhesion molecule in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells, and is also required for T cells to enter lymph nodes via interaction with L-selectin. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis. |
Specificity : | Mouse CD34 |
Immunogen : | Recombinant Mouse CD34 Protein |
Host : | Rabbit |
Isotype : | Rabbit IgG |
Species : | Mouse |
Clone : | 014 |
Applications : | Western Blot; ELISA; Immunohistochemistry |
Dilution : | Immunochemistry: IHC-P: 1 - 5 μg/mL.Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect Mouse CD34 in WB.Using a DAB detection system, the detection limit for Mouse CD34 is approximately 0.25 ng/lane under reducing conditions.Use of this antibody under non-reducing conditions is not recommended.Direct ELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect Mouse CD34. The detection limit for Mouse CD34 is approximately 0.00975 ng/well. |
Preparation : | This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse CD34. |
Format : | 0.2 μm filtered solution in PBS with 5% trehalose |
Storage : | This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Gene Name : | Cd34 CD34 antigen [ Mus musculus ] |
Official Symbol : | Cd34 |
Synonyms : | CD34; CD34 antigen; hematopoietic progenitor cell antigen CD34; cluster designation 34; AU040960; |
Gene ID : | 12490 |
mRNA Refseq : | NM_001111059 |
Protein Refseq : | NP_001104529 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; |
Function : | carbohydrate binding; sulfate binding; transcription factor binding; |
Products Types
◆ Recombinant Protein | ||
Cd34-3313M | Recombinant Mouse Cd34 protein(Met1-Thr287), His-tagged | +Inquiry |
CD34-3099H | Recombinant Human CD34 Protein, MYC/DDK-tagged | +Inquiry |
CD34-0792H | Recombinant Human CD34 Protein, GST-Tagged | +Inquiry |
Cd34-7475R | Recombinant Rat Cd34 protein(Met1-Thr291), hFc-tagged | +Inquiry |
CD34-2710H | Recombinant Human CD34 protein(81-220 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
CD34-2232MCL | Recombinant Mouse CD34 cell lysate | +Inquiry |
CD34-3047HCL | Recombinant Human CD34 cell lysate | +Inquiry |
CD34-1408RCL | Recombinant Rat CD34 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionCD34 is employed as a marker to evaluate the status of bone marrow, aiding in the diagnosis and monitoring of disorders affecting the bone marrow.
CD34 expression levels are sometimes correlated with the prognosis of certain hematologic diseases, helping clinicians predict disease outcomes and plan appropriate interventions.
CD34 expression patterns are studied to gain insights into the pathogenesis and progression of hematologic malignancies, aiding in the development of targeted therapies.
Yes, changes in CD34 expression can be indicative of the response to cancer treatments, providing valuable information for patient management.
CD34 is a target for therapeutic interventions, and research is ongoing to explore its potential for developing treatments for various diseases.
While CD34 is prominently used in hematological research, its role in angiogenesis extends its applications to cardiovascular research and regenerative medicine.
Customer Reviews (4)
Write a reviewCD34 protein may have a specific binding affinity or interaction with its target molecules or receptors, making it a valuable tool for targeted therapies or diagnostic applications.
In some cases, manufacturers may be open to collaborating with researchers to further investigate the applications and potential of CD34 protein.
If researchers require modifications or specific variants of CD34 protein for their experiments, the manufacturer could potentially offer custom protein engineering services to meet their needs.
This collaboration can involve sharing resources, expertise, and data to advance scientific understanding and therapeutic development.
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