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Rabbit Anti-Mouse CD34 Antigen Monoclonal Antibody

Cat.No. : CAB11499RM
Product Overview : Rabbit monoclonal antibody to mouse Cd34 antigen.
  • Specification
  • Gene Information
  • Related Products
Antigen Description : Mouse CD34 molecule is a member of a family of single-pass transmembrane sialomucin proteins, and is selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. As a monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. Although used clinically in hematopoietic stem cell transplantation for more than 15 years, little is known about the exact function of CD34. It may act as an adhesion molecule in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells, and is also required for T cells to enter lymph nodes via interaction with L-selectin. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.
Specificity : Mouse CD34
Immunogen : Recombinant Mouse CD34 Protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Mouse
Clone : 014
Applications : Western Blot; ELISA; Immunohistochemistry
Dilution : Immunochemistry: IHC-P: 1 - 5 μg/mL.Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect Mouse CD34 in WB.Using a DAB detection system, the detection limit for Mouse CD34 is approximately 0.25 ng/lane under reducing conditions.Use of this antibody under non-reducing conditions is not recommended.Direct ELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect Mouse CD34. The detection limit for Mouse CD34 is approximately 0.00975 ng/well.
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse CD34.
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 °C to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : Cd34 CD34 antigen [ Mus musculus ]
Official Symbol : Cd34
Synonyms : CD34; CD34 antigen; hematopoietic progenitor cell antigen CD34; cluster designation 34; AU040960;
Gene ID : 12490
mRNA Refseq : NM_001111059
Protein Refseq : NP_001104529
Pathway : Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem;
Function : carbohydrate binding; sulfate binding; transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How is CD34 used in the assessment of bone marrow health? 12/21/2022

CD34 is employed as a marker to evaluate the status of bone marrow, aiding in the diagnosis and monitoring of disorders affecting the bone marrow.

How does CD34 impact the prognosis of hematologic diseases? 05/02/2022

CD34 expression levels are sometimes correlated with the prognosis of certain hematologic diseases, helping clinicians predict disease outcomes and plan appropriate interventions.

How does CD34 contribute to the understanding of hematologic malignancies? 04/15/2021

CD34 expression patterns are studied to gain insights into the pathogenesis and progression of hematologic malignancies, aiding in the development of targeted therapies.

Can CD34 be used to monitor the effectiveness of cancer treatments? 12/06/2020

Yes, changes in CD34 expression can be indicative of the response to cancer treatments, providing valuable information for patient management.

Are there any specific therapeutic applications of CD34? 11/01/2019

CD34 is a target for therapeutic interventions, and research is ongoing to explore its potential for developing treatments for various diseases.

Is CD34 exclusively used in hematological research, or does it have applications in other medical fields? 06/26/2018

While CD34 is prominently used in hematological research, its role in angiogenesis extends its applications to cardiovascular research and regenerative medicine.

Customer Reviews (4)

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Reviews
07/02/2022

    CD34 protein may have a specific binding affinity or interaction with its target molecules or receptors, making it a valuable tool for targeted therapies or diagnostic applications.

    04/06/2019

      In some cases, manufacturers may be open to collaborating with researchers to further investigate the applications and potential of CD34 protein.

      03/03/2018

        If researchers require modifications or specific variants of CD34 protein for their experiments, the manufacturer could potentially offer custom protein engineering services to meet their needs.

        01/30/2016

          This collaboration can involve sharing resources, expertise, and data to advance scientific understanding and therapeutic development.

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