Rabbit Anti-Mouse Cathepsin D Monoclonal Antibody
Cat.No. : | CAB11522RM |
Product Overview : | Rabbit Monoclonal Antibody to Mouse Cathepsin D |
- Specification
- Gene Information
- Related Products
Antigen Description : | Cathepsin D (CTSD) is a well known lysosomal aspartyl protease and is a member of the peptidase C1 family found in almost all cells and tissues of mammals. It has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis, and can also induce apoptosis in presence of cytotoxic factors. However, on contrast, in certain studies an inhibitory role of CTSD in apoptosis was also reviewed. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases. |
Specificity : | Mouse Cathepsin D / CTSD. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA. |
Immunogen : | Recombinant Mouse Cathepsin D / CTSD Protein |
Host : | Rabbit |
Isotype : | Rabbit IgG |
Species : | Mouse |
Clone : | A103 |
Applications : | WB; ELISA |
Dilution : | Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse CTSD in WB. Using a DAB detection system, the detection limit for Mouse CTSD is approximately 1 ng/lane under non-reducing conditions and 0.5 ng/lane under reducing conditions.ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CTSD. The detection limit for Mouse CTSD is approximately 0.00975 ng/well. |
Preparation : | This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse Cathepsin D / CTSD |
Format : | 0.2 μm filtered solution in PBS with 5% trehalose |
Storage : | This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70°C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Gene Name : | Ctsd cathepsin D [ Mus musculus ] |
Official Symbol : | Ctsd |
Synonyms : | CTSD; cathepsin D; CD; CatD; |
Gene ID : | 13033 |
mRNA Refseq : | NM_009983 |
Protein Refseq : | NP_034113 |
Pathway : | Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem; |
Function : | aspartic-type endopeptidase activity; endopeptidase activity; hydrolase activity; peptidase activity; peptide binding; |
Products Types
◆ Recombinant Protein | ||
CTSD-2582H | Recombinant Human CTSD protein(71-410 aa), C-His-tagged | +Inquiry |
CTSD-786H | Recombinant Human CTSD Protein, His-tagged | +Inquiry |
CTSD-435C | Recombinant Cricetulus Griseus CTSD Protein (65-408 aa), His-SUMO-tagged | +Inquiry |
Ctsd-2369M | Recombinant Mouse Ctsd Protein, His-tagged | +Inquiry |
CTSD-2752H | Recombinant Human CTSD Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
CTSD-189H | Active Native Human Cathepsin D | +Inquiry |
CTSD-27858TH | Native Human CTSD | +Inquiry |
CTSD-26411TH | Active Native Human Cathepsin D protein | +Inquiry |
◆ Lysates | ||
CTSD-3023MCL | Recombinant Mouse CTSD cell lysate | +Inquiry |
CTSD-1735HCL | Recombinant Human CTSD cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0264 | Cathepsin D Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is an association between CTSD proteins and cognitive function. In some neurodegenerative diseases, abnormal accumulation and deposition of CTSD proteins may affect neuronal signaling and synaptic function, leading to a decline in cognitive function.
In some neurodegenerative diseases, levels of the CTSD protein may change. For example, people with Alzheimer's disease may have elevated levels of the CTSD protein. These changes may help in the diagnosis of the disease and in the assessment of the course of the disease.
For people with cognitive decline, their CTSD protein levels can be assessed by a blood or cerebrospinal fluid sample. This evaluation can help doctors understand whether the cause of cognitive decline is related to a neurodegenerative disease.
It is currently no treatment that directly targets the CTSD protein. However, some medications can reduce symptoms of neurodegenerative diseases, such as cholinesterase inhibitors such as donepezil, which can increase acetylcholine levels in synapses, which can improve cognitive function.
People with Parkinson's disease may have reduced levels of the CTSD protein. This decrease may be associated with neuronal death and impaired synaptic function. In addition, CTSD protein may also be associated with motor symptoms in patients with Parkinson's disease.
CTSD proteins play a role in Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. It may change in these diseases, leading to structural alterations and impaired signaling of neuronal synapses.
Customer Reviews (3)
Write a reviewGood at western-blot experiments.
In experiments, the biocompatibility performed well.
The experimental conditions are broad, and the experimental results are accurate and repeatable.
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