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Rabbit Anti-Mouse Endoglin Monoclonal Antibody

Cat.No.: CAB11530RM
Product Overview: Rabbit Monoclonal Antibody to Mouse Endoglin
Antigen Description: Mouse endoglin, also known as CD105, is a type Ihomodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated, cytoplasmic tail. Endoglin contains an RGD tripeptide, a key recognition structure in cellular adhesion, and suggests a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I?I receptor (TβRII) and activates the downstream signal pathway. In addition, ALK-1 is also a receptor kinase in human umbilical vein endothelial cells for endoglin threonine phosphorylation, and mutations in either result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful marker of neovascularization, and associated with several solid tumor types.
Specificity: Mouse Endoglin / CD105 / ENG. No cross-reactivity in ELISA with Human CD105; Human cell lysate (293 cell line)
Immunogen: Recombinant Mouse Endoglin / CD105 / ENG Protein
Host: Rabbit
Isotype: Rabbit IgG
Species: Mouse
Clone: A002
Applications: WB; ELISA
Dilution: Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse ENG in WB. Using a DAB detection system, the detection limit for Mouse ENG is approximately 0.5 ng/lane under non-reducing conditions and 2 ng/lane under reducing conditions.ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse ENG. The detection limit for Mouse ENG is approximately 0.00245 ng/well.
Preparation: This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Mouse Endoglin / CD105 / ENG.
Format: 0.2 μm filtered solution in PBS with 5% trehalose
Storage: This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70°C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name: Eng endoglin [ Mus musculus ]
Official Symbol: Eng
Synonyms: ENG; endoglin; transmembrane glycoprotein; cell surface MJ7/18 antigen; CD105; AI528660; AI662476; S-endoglin;
Gene ID: 13805
mRNA Refseq: NM_001146348
Protein Refseq: NP_001139820
Pathway: TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;
Function: binding; galactose binding; glycosaminoglycan binding; protein homodimerization activity; protein homodimerization activity; transforming growth factor beta binding; transforming growth factor beta binding; transforming growth factor beta receptor, cytoplasmic mediator activity; transforming growth factor beta-activated receptor activity; type I transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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