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Rabbit Anti-Human TIMD3 / HAVCR2 Monoclonal Antibody

Cat.No. : CAB11553RH
Product Overview : Rabbit Monoclonal Antibody to Human TIMD3 / HAVCR2
  • Specification
  • Gene Information
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Antigen Description : Hepatitis A virus cellular receptor 2 ( HAVCR2 ), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. TIM-3 thus serves as the surface molecule that distinguishes between the two effector populations derived from naive CD4(+) T-helper cells. TIM-3 is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. Th1 cells produce cytokines ( IFN-gamma, interleukin-2, TNF-alpha and lymphotoxin ) that are commonly associated with cell-mediated immune responses against intracellular pathogens, delayed-type hypersensitivity reactions, and induction of organ-specific autoimmune diseases. It has been identified that galectin-9 is the Tim-3 ligand, and the TIM-3-galectin-9 pathway may serve to inhibit Th1 cells during a normal immune response and may be crucial for the induction of peripheral tolerance. Dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.
Specificity : Human TIMD3 / HAVCR2. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA
Immunogen : Recombinant human TIMD3 protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Human
Cross Reactivity : 24
Clone : A25
Applications : WB; ELISA
Dilution : Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect human TIMD3 in WBELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect human TIMD3. The detection limit for human TIMD3 is approximately 0.0049 ng/well
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human TIMD3.
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : HAVCR2 hepatitis A virus cellular receptor 2 [ Homo sapiens ]
Official Symbol : HAVCR2
Synonyms : HAVCR2; hepatitis A virus cellular receptor 2; FLJ14428; Tim 3; TIM3; TIMD3; kidney injury molecule-3; T-cell membrane protein 3; T cell immunoglobulin mucin 3; T cell immunoglobulin mucin-3; T-cell immunoglobulin and mucin domain-containing protein 3; KIM-3; Tim-3; TIMD-3; HAVcr-2;
Gene ID : 84868
mRNA Refseq : NM_032782
Protein Refseq : NP_116171
MIM : 606652
UniProt ID : Q8TDQ0
Chromosome Location : 5q34

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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