Rabbit Anti-Human Interleukin 1 Receptor-like 1 Monoclonal Antibody
Cat.No. : | CAB11565RH |
Product Overview : | Rabbit Monoclonal Antibody to Human IL1RL1 |
- Specification
- Gene Information
- Related Products
Antigen Description : | The protein IL1 RL1, also known as T1, ST2, is a member of the interleukin-1 receptor family with a soluble secreted form (sST2) and a transmembrane form (ST2L). The coding gene forms a cytokine receptor gene cluster together with IL1R1(interleukin 1 receptor, type I), IL1R2(interleukin 1 receptor, type I I) and IL1RL2(interleukin 1 receptor-like 2) genes in a region mapped to chromosome 2q12. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of the protein IL1RL1 and induces production of Th2 cytokines. |
Specificity : | Human IL1RL1 / IL1R4. No cross-reactivity in ELISA with Human IL1R1, Human IL1R2, Human IL1RA, Human cell lysate (293 cell line) |
Immunogen : | Recombinant Human IL1RL1 / IL1R4 Protein |
Host : | Rabbit |
Isotype : | Rabbit IgG |
Species : | Human |
Cross Reactivity : | 003 |
Clone : | A004 |
Applications : | WB; ELISA |
Dilution : | Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IL1R4 in WB.Using a DAB detection system, the detection limit for Human IL1R4 is approximately 1 ng/lane under non-reducing conditions and 0.125 ng/lane under reducing conditions.Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL1R4. The detection limit for Human IL1R4 is approximately 0.00245 ng/well. |
Preparation : | This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human IL1RL1 / IL1R4 ( rh IL1RL1 / IL1R4; Met 1 - Phe 328; NP_003847.2) |
Format : | 0.2 μm filtered solution in PBS with 5% trehalose |
Storage : | This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. |
Gene Name : | IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ] |
Official Symbol : | IL1RL1 |
Synonyms : | IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; DER4; FIT 1; homolog of mouse growth stimulation expressed; IL33R; ST2; ST2L; ST2V; T1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; FIT-1; MGC32623; |
Gene ID : | 9173 |
mRNA Refseq : | NM_003856 |
Protein Refseq : | NP_003847 |
MIM : | 601203 |
UniProt ID : | Q01638 |
Chromosome Location : | 2q12 |
Function : | cytokine receptor activity; interleukin-1 receptor activity; interleukin-33 binding; protein binding; receptor activity; receptor signaling protein activity; |
Products Types
◆ Recombinant Protein | ||
IL1RL1-195H | Recombinant Human IL1RL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL1RL1-1009H | Active Recombinant Human ST2 Protein | +Inquiry |
IL1RL1-318H | Recombinant Human IL1RL1 Protein, Fc-tagged | +Inquiry |
IL1RL1-317H | Recombinant Human IL1RL1 Protein, His-tagged | +Inquiry |
IL1RL1-2690R | Recombinant Rat IL1RL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL1RL1-1883HCL | Recombinant Human IL1RL1 cell lysate | +Inquiry |
IL1RL1-2481HCL | Recombinant Human IL1RL1 cell lysate | +Inquiry |
IL1RL1-001MCL | Recombinant Mouse IL1RL1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL1RL1 has multiple splice variants that differ in signaling capabilities.
IL1RL1 suppresses allergic responses by inhibiting mast cell activation.
IL1RL1 is implicated in rheumatoid arthritis.
IL1RL1 increases the production of IL-4 and IL-13.
IL1RL1 is primarily membrane-bound.
IL1RL1 promotes Th2 cell differentiation.
IL1RL1 binds to IL-33 and IL-36 to initiate signaling.
IL1RL1 expression is altered in lung and breast cancer.
IL1RL1 undergoes glycosylation and phosphorylation.
IL1RL1 expression is upregulated in asthmatic conditions.
Customer Reviews (3)
Write a reviewHigh specificity in ELISA.
Suitable for flow cytometry.
Effective in allergy models.
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