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Rabbit Anti-Human Interleukin 1 Receptor-like 1 Monoclonal Antibody

Cat.No. : CAB11565RH
Product Overview : Rabbit Monoclonal Antibody to Human IL1RL1
  • Specification
  • Gene Information
  • Related Products
Antigen Description : The protein IL1 RL1, also known as T1, ST2, is a member of the interleukin-1 receptor family with a soluble secreted form (sST2) and a transmembrane form (ST2L). The coding gene forms a cytokine receptor gene cluster together with IL1R1(interleukin 1 receptor, type I), IL1R2(interleukin 1 receptor, type I I) and IL1RL2(interleukin 1 receptor-like 2) genes in a region mapped to chromosome 2q12. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of the protein IL1RL1 and induces production of Th2 cytokines.
Specificity : Human IL1RL1 / IL1R4. No cross-reactivity in ELISA with Human IL1R1, Human IL1R2, Human IL1RA, Human cell lysate (293 cell line)
Immunogen : Recombinant Human IL1RL1 / IL1R4 Protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Human
Cross Reactivity : 003
Clone : A004
Applications : WB; ELISA
Dilution : Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human IL1R4 in WB.Using a DAB detection system, the detection limit for Human IL1R4 is approximately 1 ng/lane under non-reducing conditions and 0.125 ng/lane under reducing conditions.Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human IL1R4. The detection limit for Human IL1R4 is approximately 0.00245 ng/well.
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human IL1RL1 / IL1R4 ( rh IL1RL1 / IL1R4; Met 1 - Phe 328; NP_003847.2)
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8 °C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ]
Official Symbol : IL1RL1
Synonyms : IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; DER4; FIT 1; homolog of mouse growth stimulation expressed; IL33R; ST2; ST2L; ST2V; T1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; FIT-1; MGC32623;
Gene ID : 9173
mRNA Refseq : NM_003856
Protein Refseq : NP_003847
MIM : 601203
UniProt ID : Q01638
Chromosome Location : 2q12
Function : cytokine receptor activity; interleukin-1 receptor activity; interleukin-33 binding; protein binding; receptor activity; receptor signaling protein activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Are there any splice variants of IL1RL1? 02/20/2022

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses? 11/15/2021

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases? 10/09/2021

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production? 11/21/2020

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1? 08/13/2020

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation? 02/29/2020

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands? 01/17/2020

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers? 05/09/2018

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1? 03/28/2017

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions? 08/23/2016

IL1RL1 expression is upregulated in asthmatic conditions.

Customer Reviews (3)

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Reviews
07/25/2019

    High specificity in ELISA.

    01/30/2017

      Suitable for flow cytometry.

      07/13/2016

        Effective in allergy models.

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