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Rabbit Monoclonal Antibody to Human Serine Peptidase Inhibitor, Clade E, Member 1

Cat.No. : CAB11601RH
Product Overview : Rabbit Monoclonal Antibody to Human Serine Peptidase Inhibitor, Clade E, Member 1
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Antigen Description : Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1000 serpins have been identified.Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SERPINE1 and PLANH1, is a secreted protein which belongs to the serpin family. SERPINE1 acts as bait for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Defects in SERPINE1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SERPINE1 defect in the plasma. High concentrations of SERPINE1 have been associated with thrombophilia which is an autosomal dominant disorder in which affected individuals are prone to develop serious spontaneous thrombosis
Specificity : Human PAI-1 / SerpinE1. No cross-reactivity with human cell lysate ( 293 cell line ) in WB and ELISA.
Immunogen : Recombinant Human PAI-1 / SerpinE1 Protein
Host : Rabbit
Isotype : Rabbit IgG
Species : Human
Clone : A005
Applications : Western blot; ELISA
Dilution : Western blot: This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Human SERPINE1 in WB. Using a DAB detection system, the detection limit for Human SERPINE1 is approximately 0.5 ng/lane under non-reducing conditions and reducing conditions.Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human SERPINE1. The detection limit for Human SERPINE1 is approximately 0.00975 ng/well.
Preparation : This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant Human PAI-1 / SerpinE1
Format : 0.2 μm filtered solution in PBS with 5% trehalose
Storage : This antibody can be stored at 2-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Gene Name : SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 [ Homo sapiens ]
Official Symbol : SERPINE1
Synonyms : SERPINE1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI1, PLANH1,serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; plasminogen activator inhibitor 1; PAI; plasminogen activator inhibitor; type I; serpin E1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; PAI1; PAI-1; PLANH1;
Gene ID : 5054
mRNA Refseq : NM_000602
Protein Refseq : NP_000593
MIM : 173360
UniProt ID : P05121
Chromosome Location : 7q21.3-q22
Pathway : Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Circadian Clock, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem;
Function : peptidase inhibitor activity; protease binding; protein binding; contributes_to receptor binding; serine-type endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Are there any gene polymorphisms or mutations in SERPINE1, and how do these mutations affect function? 11/13/2022

Yes, there are some genetic polymorphisms and mutations SERPINE1. These mutations may affect the structure and function of the protein they encode, which in turn affects their physiological and pathological effects. Some mutations have been shown to be involved in thrombosis and tumorigenesis.

What are the potential therapeutic applications of SERPINE1 inhibitors or activators? 10/03/2022

Inhibitors or activators targeting SERPINE1 may have potential applications for the treatment of a variety of diseases, including tumors, thrombosis, neurological diseases, etc. At present, there are some small molecule inhibitors for SERPINE1 that have entered the clinical trial stage.

How does SERPINE1 affect apoptosis and repair of nerve cells? 07/17/2022

SERPINE1 may prevent neuronal apoptosis by inhibiting serine protease activity, and may promote neuronal cell repair by regulating the activity of cytokines and growth factors.

What are the new directions or breakthroughs in the study of SERPINE1 and its related molecular mechanisms in future research? 02/18/2022

The research on SERPINE1 and its related molecular mechanisms will continue to explore its mechanism of action in human physiological and pathological processes. Future research may uncover new modes of action, new modulators, and new therapeutic applications.

Are there other inhibitors or activators in the SERPINE1? 04/03/2021

In addition to being an inhibitor of serine proteases, SERPINE1 may also be affected by other inhibitors or activators. These inhibitors or activators may work by modulating the activity or expression levels of the SERPINE1.

How is SERPINE1 related to Alzheimer's disease? 09/07/2020

In Alzheimer's disease, SERPINE1 may influence the onset and progression of the disease by regulating β amyloid deposition and neuroinflammatory processes.

Customer Reviews (3)

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Reviews
06/02/2022

    It has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.

    07/16/2021

      When used for experiments, the experimental conditions and results are highly repeatable.

      02/28/2021

        SERPINE1 has good solubility and is easy to operate and purify.

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