Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
Home > Products > Antibody > Monoclonal Antibodies > Rabbit Monoclonal Antibody to Human Tumor-Associated Calcium Signal Transducer 2

Rabbit Monoclonal Antibody to Human Tumor-Associated Calcium Signal Transducer 2

   Share
"TACSTD2" Related Products.
By Species
Chicken(1)
Human(11)
Mouse(9)
Rat(4)
By Source
+Expand -Collapse
By Tag
Fc(1)
Fc-His(1)
His(5)
N/A(1)
T7/His(1)
+Expand -Collapse
Cat.No.:
CAB11611RH
Product Overview:
Rabbit Monoclonal Antibody to Human Tumor-Associated Calcium Signal Transducer 2
Antigen Description:
Human TROP2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed by human carcinomas. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type Imembrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. The cytoplasmic tail of TROP2 possesses potential serine and tyrosine phosphorylation sites and a conserved phosphatidyl-inositol binding consensus sequence. TROP2 transduces an intracellular calcium signal and acts as a cell surface receptor, meanwhile is involved in the regulation of cell- cell adhesion. Accordingly, as a widespread stimulator of human cancer growth and a unique marker and causal factor of metastatic cancer, TROP2 is a possible candidate for diagnosis and molecular target therapy. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
Specificity:
Human TROP2 / TACSTD2. No cross-reactivity in ELISA withHuman BCAM / CD239; Human VCAM1 / CD106; Human ICAM1 / CD54; Human CD146 / MCAM / MUC18; Human CD171 / NCAML1 / L1CAM; Human Cadherin-1 / E-cadherin / CDH1 / CD324
Immunogen:
Recombinant human TROP2 protein
Host:
Rabbit
Isotype:
Rabbit IgG
Species:
Human
Clone:
A31
Applications:
Immunochemistry; Western blot; ELISA
Dilution:
IHC-P: 1-10 μg/mLWestern blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect human TROP2 in WB. Using a DAB detection system, the detection limit for human TROP2 is approximately 0.5 ng/lane under non-reducing conditions. Use of this antibody under reducing conditions is not recommendedDirect ELISA: This antibody can be used at 0.1- 0.2 μg/mL with the appropriate secondary reagents to detect human TROP2. The detection limit for human TROP2 is 0.00245 ng/well
Preparation:
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human TROP2 extracellular domain
Format:
0.2 μm filtered solution in PBS with 5% trehalose
Storage:
This antibody can be stored at 2-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.


Online Inquiry    
Note: There will be extra charge for optional service!
Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
Please input "biomart" as verification code.
Please review Creative Biomart's privacy policy for more information.
Price does not include shipping and packaging costs.Request quote for final price.

If you have any other questions, please call
+1-631-559-9269.

online inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.

45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

facebook twitter linkedin google plus google plus

Join 10 other subscribers

24x7
CUSTOMER SERVICE
Easy access to products and services you need from our library via powerful searching tools
Copyright © 2007 - 2016 Creative Biomart. All Rights Reserved.