Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
Home > Products > Antibody > Monoclonal Antibodies > Rabbit Monoclonal Antibody to Human TIMP Metallopeptidase Inhibitor 1

Rabbit Monoclonal Antibody to Human TIMP Metallopeptidase Inhibitor 1

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Cat.No.:
CAB11617RH
Product Overview:
Rabbit Monoclonal Antibody to Human TIMP Metallopeptidase Inhibitor 1
Antigen Description:
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and the inducible form TIMP1 is a glycoprotein expressed by a variety of cell types. It inhibits most MMPs except membrane-type MMP subfamily by forming non-covalent binary complex, but also interacts with the hemopexin-like (PEX) domain of pro MMP-9. TIMP1 has been identified as a multifunctional molecule with divergent functions. It exhibits keratinocyte and fibroblast growth factor-like activity and acts as a cell survival factor, and additionally participates in tumor metastasis, angiogenesis, inflammatory responses, as well as CNS homeostasis. TIMP1 overexpression may serve to help identify patients with particularly aggressive disease for adjuvant treatments.
Specificity:
Human TIMP1. No cross-reactivity with human TIMP2 and human cell lysate ( 293 cell line ) in WB and ELISA
Immunogen:
Recombinant human TIMP1 protein
Host:
Rabbit
Isotype:
Rabbit IgG
Species:
Human
Clone:
A005
Applications:
Western blot; ELISA
Dilution:
Western blot: This antibody can be used at 1 - 2 μg/mL with the appropriate secondary reagents to detect human TIMP1 in WB. Using a DAB detection system, the detection limit for human TIMP1 is approximately 1 ng/lane under non-reducing conditions and 10 ng/lane under reducing conditionsDirect ELISA: This antibody can be used at 0.1 - 0.2 μg/mL with the appropriate secondary reagents to detect human TIMP1. The detection limit for human TIMP1 is approximately 0.00975 ng/well
Preparation:
This antibody was obtained from a rabbit immunized with purified, human cell-derived, recombinant human TIMP1
Format:
0.2 μm filtered solution in PBS with 5% trehalose
Storage:
This antibody can be stored at 2-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 to -70 °C. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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