Recombinant Human AK1 protein, His-tagged
Cat.No. : | AK1-1344H |
Product Overview : | Recombinant Human AK1 protein(AAH01116.1)(Met1-Lys194), fused with His tag, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Supplied as sterile PBS, 10% glycerol, pH 7.5Please contact us for any concerns or special requirements.Please refer to the specific buffer information in the hard copy of CoA. |
Molecular Mass : | The recombinant human AK1 consisting of 209 amino acids and has a calculated molecular mass of 23.5 kDa. It migrates as an approximately 25 kDa band in SDS-PAGE under reducing conditions. |
Protein Length : | Met1-Lys194 |
Purity : | > 90 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | AK1 adenylate kinase 1 [ Homo sapiens ] |
Official Symbol : | AK1 |
Synonyms : | AK1; adenylate kinase 1; adenylate kinase isoenzyme 1; AK 1; myokinase; ATP-AMP transphosphorylase 1; |
Gene ID : | 203 |
mRNA Refseq : | NM_000476 |
Protein Refseq : | NP_000467 |
MIM : | 103000 |
UniProt ID : | P00568 |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Q&As
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Q&As (25)
Ask a questionBesides its role in energy metabolism, AK1 protein has also been implicated in cell cycle regulation, DNA damage repair, regulation of protein-protein interactions, and modulation of cellular signaling pathways.
While adenylate kinase deficiency is the primary clinical consequence associated with AK1 protein mutations, altered AK1 expression or activity has been observed in some pathological conditions, including cancer, neurodegenerative disorders, and cardiovascular diseases.
AK1 protein is ubiquitously expressed across different tissues and organs in the body.
Yes, mutations in the AK1 gene can lead to a rare genetic disorder known as hemolytic anemia due to adenylate kinase deficiency. This condition is characterized by the destruction of red blood cells.
While specific therapeutic agents targeting AK1 protein are not currently available, there is ongoing research to explore its potential as a therapeutic target. Manipulating AK1 activity, expression, or regulation may hold promise for the treatment of certain diseases, particularly those where altered metabolism plays a role.
AK1 protein is predominantly found in the cytoplasm and the cytoskeleton of cells.
Yes, alternative splicing of the AK1 gene can give rise to different isoforms of AK1 protein. These isoforms might have variations in their enzymatic activity, subcellular localization, or interaction with other proteins. Further studies are needed to fully understand the functional significance of AK1 protein isoforms.
Some drugs may indirectly affect AK1 protein activity by altering cellular metabolism or energy levels. Drugs that target cellular respiration or ATP production, such as certain chemotherapeutic agents or metabolic modulators, may have an impact on AK1 protein activity, although it may not be their primary target.
Yes, AK1 protein has been reported to interact with a variety of other proteins involved in cellular processes, including cytoskeletal proteins, enzymes involved in ATP synthesis, and proteins involved in cell signaling pathways.
Future research on AK1 protein aims to elucidate its exact physiological roles in different tissues and organs. Additionally, understanding the underlying mechanisms of AK1-related disorders may lead to the development of targeted therapies.
There is evidence to suggest that AK1 protein may play a role in neurodegenerative disorders. Studies have shown altered AK1 expression and activity in the brains of individuals with Alzheimer's disease and Parkinson's disease. However, the exact mechanisms and implications are still being investigated.
Currently, there are no specific therapeutics targeting AK1 protein. However, further research on AK1 and its dysregulation may offer potential avenues for intervention in disorders related to adenylate metabolism.
Yes, animal models and cell lines are commonly used to study AK1 protein. Mouse models with AK1 gene knockout or overexpression have been generated to investigate its role in various physiological and pathological conditions. Additionally, cell lines derived from different tissues can be used to examine AK1 protein function and regulation in vitro.
Some small-molecule inhibitors of AK1 protein have been developed for research purposes, but they are not currently used in clinical settings. There is limited information on activators of AK1 protein.
AK1 protein is often studied through techniques such as protein purification, enzyme activity assays, gene knockout or overexpression experiments, immunofluorescence microscopy, and biochemical analyses to investigate its function, regulation, and potential therapeutic implications.
While AK1 protein is not commonly used as a diagnostic marker, its deficiency can be detected through genetic testing for the diagnosis of hemolytic anemia due to adenylate kinase deficiency.
While AK1 protein's role in immune system function is not well-characterized, some studies have suggested its involvement in T-cell activation and proliferation. However, further research is needed to clarify the specific mechanisms and implications in immune function.
While there is limited research on AK1 protein's role in fertility and reproductive health, some studies have suggested its involvement in sperm motility and function. Further investigations are needed to fully understand the potential impact of AK1 protein on reproductive processes.
Yes, AK1 protein can interact with various other proteins to form protein complexes or participate in cellular pathways. For example, it has been reported to physically interact with certain chaperones, signaling molecules, and other enzymes involved in nucleotide metabolism. These interactions can regulate AK1 protein activity and influence its cellular functions.
While there are currently no specific therapeutic agents targeting AK1 protein, some studies have explored its potential as a target in certain diseases, such as cancer. Manipulating AK1 activity or expression may have implications for the treatment of certain malignancies.
Currently, there is limited evidence to suggest using AK1 protein as a prognostic marker. However, further research is needed to explore its potential value as a prognostic indicator in specific diseases.
Yes, mutations in the AK1 gene have been linked to adenylate kinase deficiency, an autosomal recessive disorder characterized by hemolytic anemia and muscle weakness. It is a rare condition, and patients often present with symptoms such as fatigue, exercise intolerance, and elevated levels of certain molecules in the blood.
The activity of AK1 protein is regulated by various factors, including the concentrations of its substrates and products (AMP, ADP, and ATP), pH levels, and changes in cellular redox status.
AK1 protein plays a role in maintaining proper energy metabolism by regulating adenylate pools in the cell. It contributes to the production of ATP, the energy currency of the cell.
AK1 protein is expressed in a wide range of tissues, but its expression levels can vary. It is highly expressed in tissues with high energy demands, such as skeletal muscle, heart, and brain. However, it is also found in other tissues, albeit at lower levels. This widespread expression reflects the importance of AK1 protein in nucleotide metabolism and energy homeostasis throughout the body.
Customer Reviews (4)
Write a reviewAK1 protein boasts an exemplary caliber, rendering it a remarkable choice that impeccably aligns with my experimental prerequisites.
the manufacturer's commitment to excellence extends beyond the mere production of the AK1 protein.
Their exceptional technical support team stands ready to tackle any obstacles or queries I may encounter during my experimental journey.
Its exceptional quality and consistency instill confidence in attaining accurate and reproducible results
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