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Recombinant Mouse Erbb3, His tagged

Cat.No. : Erbb3-2515M
Product Overview : Recombinant Mouse Erbb3 (Q61526) extracellular domain (Met 1-His 641), fused with a C-terminal polyhistidine tag, was produced in Human Cell.
  • Specification
  • Gene Information
  • Related Products
Source : Human Cells
Species : Mouse
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4
Molecular Mass : The secreted recombinant mouse ERBB3 comprises 633 amino acids and has a calculated molecular mass of 70 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 95 kDa in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Mus musculus ]
Official Symbol : Erbb3
Gene ID : 13867
mRNA Refseq : NM_010153
Protein Refseq : NP_034283

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential side effects of targeting ERBB3 in cancer therapy? 03/08/2023

Potential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.

How does ERBB3 contribute to resistance to certain cancer therapies? 01/29/2023

ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.

How does ERBB3 interact with other receptors in the EGFR family? 11/07/2022

ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.

Can ERBB3 be used as a biomarker for prognosis in cancer patients? 10/26/2022

Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.

In which types of cancers is ERBB3 commonly overexpressed? 10/19/2020

ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.

Customer Reviews (3)

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Reviews
10/28/2021

    Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

    08/11/2021

      Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

      03/03/2020

        The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

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