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Recombinant Mouse Map2k4 protein(Ala2-Asp397), His&GST-tagged

Cat.No. : Map2k4-1351M
Product Overview : Recombinant Mouse MAP2K4 (P47809) (Ala 2-Asp 397) was expressed in Insect Cells, fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Source : Insect Cells
Species : Mouse
Tag : N-His&GST
Protein length : Ala2-Asp397
Form : Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.5 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The secreted recombinant mouse MAP2K4/GST chimera consists of 633 amino acids and has a calculated molecular mass of 72 kDa. The recombinant protein migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : Map2k4 mitogen-activated protein kinase kinase 4 [ Mus musculus ]
Official Symbol : Map2k4
Synonyms : MAP2K4; mitogen-activated protein kinase kinase 4; dual specificity mitogen-activated protein kinase kinase 4; MEK 4; JNKK 1; MAPKK 4; JNK kinase 1; MAPK/ERK kinase 4; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; MAP kinase kinase 4; JNK-activating kinase 1; C-JUN N-terminal kinase kinase 1; mitogen activated protein kinase kinase 4, variant 1; MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4;
Gene ID : 26398
mRNA Refseq : NM_009157
Protein Refseq : NP_033183

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there existing or potential therapeutic strategies targeting MAP2K4? 06/12/2022

Targeting MAP2K4 may provide therapeutic benefits in cancer, modulating cell survival and response to stress.

What role does MAP2K4 play in cellular stress response? 03/24/2022

MAP2K4 helps cells respond to stress, modulating survival and death pathways.

How is MAP2K4 implicated in cancer development and progression? 04/28/2020

Dysregulation of MAP2K4 has been linked to cancer, affecting cell growth and resistance to apoptosis.

How does MAP2K4 contribute to the JNK and p38 MAPK pathways? 02/25/2020

It phosphorylates and activates JNK and p38, transmitting signals in response to stress.

How is the activity of MAP2K4 regulated within cells? 10/29/2019

Its activity is regulated by phosphorylation and interaction with other signaling proteins.

In which cellular processes is MAP2K4 involved? 10/07/2019

MAP2K4 is involved in processes like cell growth, apoptosis, and stress response.

What is the primary biological function of MAP2K4 in cellular signaling? 11/23/2018

MAP2K4 is a kinase that plays a critical role in activating the JNK and p38 MAPK signaling pathways.

Customer Reviews (3)

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10/25/2021

    Good value, high quality.

    04/03/2021

      Pure product, no issues.

      03/13/2021

        Reliable, worked as described.

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