| Cat. No. : |
ALDH2-27037TH |
| Description : |
This protein belongs to the aldehyde dehydrogenase family of proteins. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. A remarkably hig-her frequency of acute alcohol intoxication among Orienta-ls than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The in-crea-sed exposure to acetaldehyde in individuals with the cat-alyti-cally inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in mu-ltiple transcript variants encoding distinct isoforms. |
| Source : |
E. coli. |
| Biologicalactivity : |
Specific activity is < 0.2 units/ml, and was obtained by measuring the increase of NADP in absorbance at 340 nm resulting from the reduction of NAD. One unit will oxidize 1.0 umole of acetaldehyde to acetic acid per minute at pH 8.0 at 25C in the presence of beta-NAD, potassium and thiols. |
| Formulation : |
Liquid. |
| Purity : |
>90% by SDS-PAGE |
| Sequencesof amino acids : |
MSAAATQAVP APNQQPEVFC NQIFINNEWH DAVSRKTFPT VNPSTGEVIC QVAEGDKEDV DKAVKAARAA FQLGSPWRRM DASHRGRLLN RLADLIERDR TYLAALETLD NGKPYVISY L VDLDMVLKCL RYYAGWADKY HGKTIPIDGD FFSYTRHEPV GVCGQIIPWN FPLLMQAWKL GPALATGNVV VMKVAEQTPL TALYVANLIK EAGFPPGVVN IVPGFGPTAG AAIASHE DVD KVAFTGSTEI GRVIQVAAGS SNLKRVTLEL GGKSPNIIMS DADMDWAVEQ AHFALFFNQG QCCCAGSRTF VQEDIYDEFV ERSVARAKSR VVGNPFDSKT EQGPQVDETQ FKKIL GYINT GKQEGAKLLC GGGIAADRGY FIQPTVFGDV QDGMTIAKEE IFGPVMQILK FKTIEEVVGR ANNSTYGLAA AVFTKDLDKA NYLSQALQAG TVWVNCYDVF GAQSPFGGYK MSG SGRELGE YGLQAYTEVK TVTVKVPQKN S |
| SequenceSimilarities : |
Belongs to the aldehyde dehydrogenase family. |
| Storage buffer : |
Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 7.5 |
| Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
| OfficialSymbol : |
ALDH2 |
