Rabbit Anti-Human CD4 Monoclonal Antibody

Cat. No.: CABTT-005RH
ProductOverview: Monoclonal Antibody toCD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Antigen Description: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Clone: FQS7277
Host animal: Rabbit
CrossReactivity: Human
Isotype: IgG1
Immunogen: Recombinant fragment corresponding to the extracellular domain of Human CD4
Positive control: Human fetal thymus and Human lymph node lysates, THP-1 cells
Application: WB; ICC/IF; Flow Cyt
Sequencesimilarities: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Post-translationalmodifications: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular localization: Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Form: Liquid
Purity: Tissue culture supernatant
Storage Buffer: pH: 7.40; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Storage: Store at -20°C. Stable for 12 months at -20°C
nullValue_other:
FunctionMHC class II protein binding; coreceptor activity; enzyme binding; extracellular matrix structural constituent; glycoprotein binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity; transmembrane signaling receptor activity; zinc ion binding
Gene Name: CD4 CD4 molecule [ Homo sapiens ]
Official Symbol: CD4
Synonyms: CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD 4; CD4 (L3T4); CD4 antigen; CD4+ Lymphocyte deficiency; CD4_HUMAN; CD4mut; L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; MGC165891; OTTHUMP00000238897; p55; T cell antigen T4; T cell differentiation antigen L3T4; T cell OKT4 deficiency; T cell surface antigen T4/Leu 3; cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; W3/25; W3/25 antigen
Gene ID: 920
mRNA Refseq: NM_000616
Protein Refseq: NP_000607
MIM: 186940
UniProt ID: P01730
Chromosome Location: 12p13.31
Pathway: Adaptive Immune System; Alpha-defensins; Antigen processing and presentation; Arf1 pathway, organism-specific; Binding and entry of HIV virion; CXCR4-mediated signaling events; Cell adhesion molecules (CAMs); Defensins; Downstream TCR signaling; Nef Mediated CD4 Down-regulation

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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