Rabbit Anti-Human CD4 Monoclonal Antibody
Cat.No. : | CABTT-005RH |
- Specification
- Gene Information
- Related Products
Cat. No. : | CABTT-005RH | ||
ProductOverview : | Monoclonal Antibody toCD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. | ||
Antigen Description : | This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. | ||
Clone : | FQS7277 | ||
Host animal : | Rabbit | ||
CrossReactivity : | Human | ||
Isotype : | IgG1 | ||
Immunogen : | Recombinant fragment corresponding to the extracellular domain of Human CD4 | ||
Positive control : | Human fetal thymus and Human lymph node lysates, THP-1 cells | ||
Application : | WB; ICC/IF; Flow Cyt | ||
Sequencesimilarities : | Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. | ||
Post-translationalmodifications : | Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. | ||
Cellular localization : | Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. | ||
Form : | Liquid | ||
Purity : | Tissue culture supernatant | ||
Storage Buffer : | pH: 7.40; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA | ||
Storage : | Store at -20°C. Stable for 12 months at -20°C | ||
nullValue_other : |
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Gene Name : | CD4 CD4 molecule [ Homo sapiens ] |
Official Symbol : | CD4 |
Synonyms : | CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD 4; CD4 (L3T4); CD4 antigen; CD4+ Lymphocyte deficiency; CD4_HUMAN; CD4mut; L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; MGC165891; OTTHUMP00000238897; p55; T cell antigen T4; T cell differentiation antigen L3T4; T cell OKT4 deficiency; T cell surface antigen T4/Leu 3; cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; W3/25; W3/25 antigen |
Gene ID : | 920 |
mRNA Refseq : | NM_000616 |
Protein Refseq : | NP_000607 |
MIM : | 186940 |
UniProt ID : | P01730 |
Chromosome Location : | 12p13.31 |
Pathway : | Adaptive Immune System; Alpha-defensins; Antigen processing and presentation; Arf1 pathway, organism-specific; Binding and entry of HIV virion; CXCR4-mediated signaling events; Cell adhesion molecules (CAMs); Defensins; Downstream TCR signaling; Nef Mediated CD4 Down-regulation |
Products Types
◆ Lysates | ||
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CD4-2580MCL | Recombinant Mouse CD4 cell lysate | +Inquiry |
CD4-1905HCL | Recombinant Human CD4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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