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Rabbit Anti-Human CD4 Monoclonal Antibody

Cat.No. : CABTT-005RH
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  • Gene Information
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Cat. No. : CABTT-005RH
ProductOverview : Monoclonal Antibody toCD4; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Antigen Description : This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Clone : FQS7277
Host animal : Rabbit
CrossReactivity : Human
Isotype : IgG1
Immunogen : Recombinant fragment corresponding to the extracellular domain of Human CD4
Positive control : Human fetal thymus and Human lymph node lysates, THP-1 cells
Application : WB; ICC/IF; Flow Cyt
Sequencesimilarities : Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Post-translationalmodifications : Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular localization : Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Form : Liquid
Purity : Tissue culture supernatant
Storage Buffer : pH: 7.40; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Storage : Store at -20°C. Stable for 12 months at -20°C
nullValue_other :
FunctionMHC class II protein binding; coreceptor activity; enzyme binding; extracellular matrix structural constituent; glycoprotein binding; protein binding; protein homodimerization activity; protein kinase binding; receptor activity; transmembrane signaling receptor activity; zinc ion binding
Gene Name : CD4 CD4 molecule [ Homo sapiens ]
Official Symbol : CD4
Synonyms : CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD 4; CD4 (L3T4); CD4 antigen; CD4+ Lymphocyte deficiency; CD4_HUMAN; CD4mut; L3T4; Leu3; Ly-4; Lymphocyte antigen CD4; MGC165891; OTTHUMP00000238897; p55; T cell antigen T4; T cell differentiation antigen L3T4; T cell OKT4 deficiency; T cell surface antigen T4/Leu 3; cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; W3/25; W3/25 antigen
Gene ID : 920
mRNA Refseq : NM_000616
Protein Refseq : NP_000607
MIM : 186940
UniProt ID : P01730
Chromosome Location : 12p13.31
Pathway : Adaptive Immune System; Alpha-defensins; Antigen processing and presentation; Arf1 pathway, organism-specific; Binding and entry of HIV virion; CXCR4-mediated signaling events; Cell adhesion molecules (CAMs); Defensins; Downstream TCR signaling; Nef Mediated CD4 Down-regulation

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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