Active Recombinant Human RETN

• Cat.No.: RETN-61H

Specification

• Cat. No.: RETN-61H
• Overview: Human Resistin Recombinant Protein was expressed in E. coli with amino acids Ser17-Pro108 accession number NP_065148.
• Description: Resistin is a peptide hormone belonging to the RELM (Resistin-Like Molecule) family that also includes RELMα, RELMβ, and RELMγ. In mice, resistin is secreted in high levels by adipocytes, and overexpression has been linked to insulin resistance and obesity. The link between resistin and glucose metabolism in humans is still unclear, and it has instead been found to play a role in the inflammatory process. The main source of resistin in humans is peripheral blood monocytes, which upregulate expression in response to IL-6 and TNFα. Elevated levels of circulating resistin are associated with chronic inflammatory conditions and cardiovascular disease.
• Source: E. coli
• Species: Human
• Predicted MolecularMass: 9.9 kDa
• Formulation: Sterile liquid; phosphate buffered saline 1% BSA, pH 7.2. 0.22 um filtered.
• Purity: > 97%, as determined by SDS-PAGE
• Concentration: 0.1 mg/mL
• Endotoxin: Less than 0.1 ng/ug cytokine as determined by the LAL assay.
• Bioactivity: The ED50 of this protein, as measured by stimulation of lypolysis in human adipocytes, is 7-30 ug/mL. This corresponds to a specific activity of 143-33 Units/mg.
• Handling Conditions: For best recovery, quick-spin vial prior to opening. Use in sterile envrioment.
• Storage: Store at less than or equal to -70°C.
• OfficialSymbol: RETN

Gene Information

• Gene Name: RETN resistin [ Homo sapiens ]
• Synonyms: RETN; Cysteine-rich secreted protein; FIZZ3; Adipose tissue-specific secretory factor (ADSF); C/EBP-epsilon; regulated myeloid-sepcific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like-2; ADSF; MGC126603; MGC126609; RETN1; XCP1; resistin; MGC126609; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1 ; Adipose tissue-specific secretory factor; C/EBP-epsilon regulated myeloid-specific secreted; cysteine-rich protein precursor 1; cysteine-rich protein; Cysteine-rich secreted protein FIZZ3; found in inflammatory zone 3
• Gene ID: 56729
• mRNA Refseq: NM_020415
• Protein Refseq: NP_065148
• MIM: 605565
• UniProt ID: Q9HD89
• Chromosome Location: 19p13.2
• Pathway: Adipogenesis, organism-specific biosystem
• Function: hormone activity