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Recombinant Human Allograft Inflammatory Factor 1, His-tagged

Cat.No. : AIF1-6900H
Product Overview : Recombinant human AIF1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 18.9 kDa.
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  • Gene Information
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Description : AIF1 (Allograft inflammatory factor 1) is induced by cytokines and interferon. This protein is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. AIF1 is a cytoplasm, calcium-binding protein whose expression in transplanted human hearts correlates with rejection and development of coronary artery vasculopathy (CAV).
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 200mM NaCl.
Molecular Mass : 18.9 kDa (167aa), confirmed by MALDI-TOF
Protein length : 1-147aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM ILMYEEKARE KEKPTGPPAK KAISELP
Purity : >95% by SDS-PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Name : AIF1 allograft inflammatory factor 1 [ Homo sapiens ]
Official Symbol : AIF1
Synonyms : AIF1; allograft inflammatory factor 1; AIF 1; Em:AF129756.17; IBA1; interferon gamma responsive transcript; ionized calcium binding adapter molecule 1; IRT 1; protein G1; ionized calcium-binding adapter molecule 1; allograft inflammatory factor-1 splice variant Hara-1; IRT1; AIF-1; IRT-1;
Gene ID : 199
mRNA Refseq : NM_001623
Protein Refseq : NP_001614
MIM : 601833
UniProt ID : P55008
Chromosome Location : 6p21.3
Function : actin filament binding; calcium ion binding; calcium ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (14)

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Does AIF1 have any role in cardiovascular diseases? 05/20/2023

Yes, AIF1 has been implicated in cardiovascular diseases, particularly in atherosclerosis, a condition in which plaque builds up in the arteries. AIF1 is involved in the activation of macrophages, which play a key role in the development of atherosclerosis. AIF1 expression has been found to be increased in atherosclerotic plaques.

Can AIF1 be used for gene therapy? 12/04/2022

AIF1 has not been widely studied as a potential target for gene therapy. However, it is possible that its role in immune cell activation and inflammation could be harnessed for therapeutic purposes.

Can AIF1 be used as a biomarker for disease diagnosis? 05/30/2022

AIF1 has been suggested as a potential biomarker for several diseases, including Alzheimer's disease and multiple sclerosis. However, more research is needed to validate its use as a diagnostic biomarker.

Is there any genetic variation in the AIF1 gene? 03/06/2022

Yes, there are genetic variations in the AIF1 gene that have been associated with various diseases. For example, a single nucleotide polymorphism (SNP) in the AIF1 gene has been linked to an increased risk of rheumatoid arthritis, while another SNP has been associated with autoimmune thyroid disease.

What are the different isoforms of AIF1? 02/11/2022

There are three known isoforms of AIF1: AIF1α, AIF1β, and AIF1γ. AIF1α is the most well-known isoform and is expressed in macrophages, microglia, and other immune cells. AIF1β is expressed in the thymus and spleen, while AIF1γ is expressed in the testis.

Can AIF1 be used as a biomarker for any diseases? 03/23/2021

AIF1 has been proposed as a potential biomarker for various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. However, more research is needed to establish its usefulness as a biomarker and determine the best way to measure AIF1 levels.

What are the potential clinical applications of AIF1? 11/02/2020

AIF1 is a potential target for the development of therapies for various diseases, including Alzheimer's disease, multiple sclerosis, and cancer. It could also be used as a diagnostic biomarker for certain diseases.

Is AIF1 involved in neuroinflammation and neurodegenerative diseases? 06/04/2020

Yes, AIF1 is involved in neuroinflammation and neurodegenerative diseases. It is expressed in microglia, the immune cells of the central nervous system (CNS), and plays a role in activating these cells and promoting neuroinflammation. Increased AIF1 expression has been observed in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

What are some potential therapeutic strategies for targeting AIF1? 09/18/2019

Potential therapeutic strategies for targeting AIF1 include developing drugs that inhibit its expression or function, or developing immunomodulatory therapies that modulate immune cell activation more broadly. However, more research is needed to determine the feasibility and safety of these approaches.

How is AIF1 protein detected in cells? 11/22/2018

AIF1 protein can be detected in cells using various techniques, including immunohistochemistry, immunofluorescence, Western blotting, and flow cytometry. Antibodies that specifically recognize AIF1 can be used to visualize its expression and localization within cells.

Can AIF1 be targeted therapeutically? 10/06/2018

AIF1 is a potential target for therapeutic interventions aimed at reducing inflammation in various diseases. However, more research is needed to develop effective therapies that specifically target AIF1.

Are there any known mutations in the AIF1 gene that cause disease? 07/06/2017

There are currently no known mutations in the AIF1 gene that cause disease, although genetic variation in the gene may influence susceptibility to certain diseases.

Are there any drugs that target AIF1? 07/15/2015

There are currently no drugs that specifically target AIF1, although some drugs that target immune cells, such as corticosteroids and immunosuppressive agents, may indirectly affect AIF1 expression and function.

Is AIF1 involved in cancer? 07/01/2015

AIF1 has been found to be overexpressed in several types of cancer, including breast cancer, pancreatic cancer, and esophageal cancer. Its exact role in cancer is not yet fully understood, but it is thought to play a role in tumor progression and metastasis.

Customer Reviews (4)

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Reviews
11/06/2022

    Whether I require assistance with troubleshooting experimental protocols or guidance on data analysis, their reliable and prompt support will undoubtedly prove invaluable in finding solutions.

    10/06/2020

      The AIF1 protein displays exceptional quality and is precisely aligned with my experimental requirements.

      06/08/2020

        Its reliability and the manufacturer's expertise will undoubtedly contribute to the success and significance of my research.

        06/24/2019

          the AIF1 protein's remarkable quality and the manufacturer's excellent technical support make it an ideal choice to fulfill my experimental needs.

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