Recombinant Human Allograft Inflammatory Factor 1, His-tagged
Cat.No. : | AIF1-6900H |
Product Overview : | Recombinant human AIF1, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 18.9 kDa. |
- Specification
- Gene Information
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Description : | AIF1 (Allograft inflammatory factor 1) is induced by cytokines and interferon. This protein is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. AIF1 is a cytoplasm, calcium-binding protein whose expression in transplanted human hearts correlates with rejection and development of coronary artery vasculopathy (CAV). |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 20% glycerol, 200mM NaCl. |
Molecular Mass : | 18.9 kDa (167aa), confirmed by MALDI-TOF |
Protein length : | 1-147aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MSQTRDLQGG KAFGLLKAQQ EERLDEINKQ FLDDPKYSSD EDLPSKLEGF KEKYMEFDLN GNGDIDIMSL KRMLEKLGVP KTHLELKKLI GEVSSGSGET FSYPDFLRMM LGKRSAILKM ILMYEEKARE KEKPTGPPAK KAISELP |
Purity : | >95% by SDS-PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Gene Name : | AIF1 allograft inflammatory factor 1 [ Homo sapiens ] |
Official Symbol : | AIF1 |
Synonyms : | AIF1; allograft inflammatory factor 1; AIF 1; Em:AF129756.17; IBA1; interferon gamma responsive transcript; ionized calcium binding adapter molecule 1; IRT 1; protein G1; ionized calcium-binding adapter molecule 1; allograft inflammatory factor-1 splice variant Hara-1; IRT1; AIF-1; IRT-1; |
Gene ID : | 199 |
mRNA Refseq : | NM_001623 |
Protein Refseq : | NP_001614 |
MIM : | 601833 |
UniProt ID : | P55008 |
Chromosome Location : | 6p21.3 |
Function : | actin filament binding; calcium ion binding; calcium ion binding; |
Products Types
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionYes, AIF1 has been implicated in cardiovascular diseases, particularly in atherosclerosis, a condition in which plaque builds up in the arteries. AIF1 is involved in the activation of macrophages, which play a key role in the development of atherosclerosis. AIF1 expression has been found to be increased in atherosclerotic plaques.
AIF1 has not been widely studied as a potential target for gene therapy. However, it is possible that its role in immune cell activation and inflammation could be harnessed for therapeutic purposes.
AIF1 has been suggested as a potential biomarker for several diseases, including Alzheimer's disease and multiple sclerosis. However, more research is needed to validate its use as a diagnostic biomarker.
Yes, there are genetic variations in the AIF1 gene that have been associated with various diseases. For example, a single nucleotide polymorphism (SNP) in the AIF1 gene has been linked to an increased risk of rheumatoid arthritis, while another SNP has been associated with autoimmune thyroid disease.
There are three known isoforms of AIF1: AIF1α, AIF1β, and AIF1γ. AIF1α is the most well-known isoform and is expressed in macrophages, microglia, and other immune cells. AIF1β is expressed in the thymus and spleen, while AIF1γ is expressed in the testis.
AIF1 has been proposed as a potential biomarker for various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. However, more research is needed to establish its usefulness as a biomarker and determine the best way to measure AIF1 levels.
AIF1 is a potential target for the development of therapies for various diseases, including Alzheimer's disease, multiple sclerosis, and cancer. It could also be used as a diagnostic biomarker for certain diseases.
Yes, AIF1 is involved in neuroinflammation and neurodegenerative diseases. It is expressed in microglia, the immune cells of the central nervous system (CNS), and plays a role in activating these cells and promoting neuroinflammation. Increased AIF1 expression has been observed in various neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
Potential therapeutic strategies for targeting AIF1 include developing drugs that inhibit its expression or function, or developing immunomodulatory therapies that modulate immune cell activation more broadly. However, more research is needed to determine the feasibility and safety of these approaches.
AIF1 protein can be detected in cells using various techniques, including immunohistochemistry, immunofluorescence, Western blotting, and flow cytometry. Antibodies that specifically recognize AIF1 can be used to visualize its expression and localization within cells.
AIF1 is a potential target for therapeutic interventions aimed at reducing inflammation in various diseases. However, more research is needed to develop effective therapies that specifically target AIF1.
There are currently no known mutations in the AIF1 gene that cause disease, although genetic variation in the gene may influence susceptibility to certain diseases.
There are currently no drugs that specifically target AIF1, although some drugs that target immune cells, such as corticosteroids and immunosuppressive agents, may indirectly affect AIF1 expression and function.
AIF1 has been found to be overexpressed in several types of cancer, including breast cancer, pancreatic cancer, and esophageal cancer. Its exact role in cancer is not yet fully understood, but it is thought to play a role in tumor progression and metastasis.
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