Recombinant Human Prostaglandin D2 Synthase 21kDa (brain), His-tagged

• Cat.No.: PTGDS-2501H
• Product Overview: Recombinant human PTGDS protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 20.9 kDa.

Specification

• Description: PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a beta-amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer"s disease.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 1mM EDTA, 0.1M NaCl.
• Molecular Mass: 20.9 kDa (189aa), confirmed by MALDI-TOF
• Protein length: 23-190aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MAPEAQVSVQ PNFQQDKFLG RWFSAGLASN SSWLREKKAA LSMCKSVVAP ATDGGLNLTS TFLRKNQCET RTMLLQPAGS LGSYSYRSPH WGSTYSVSVV ETDYDQYALL YSQGSKGPGE DFRMATLYSR TQTPRAELKE KFTAFCKAQG FTEDTIVFLP QTDKCMTEQ
• Purity: >90% by SDS-PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles.
• Concentration: 1 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PTGDS prostaglandin D2 synthase 21kDa (brain) [ Homo sapiens ]
• Official Symbol: PTGDS
• Synonyms: PTGDS; prostaglandin D2 synthase 21kDa (brain); prostaglandin D2 synthase (21kD, brain); prostaglandin-H2 D-isomerase; L PGDS; lipocalin type prostaglandin D synthase; PGDS; cerebrin-28; PGD2 synthase; beta-trace protein; prostaglandin D synthase; prostaglandin-D2 synthase; glutathione-independent PGD synthase; glutathione-independent PGD synthetase; lipocalin-type prostaglandin D synthase; lipocalin-type prostaglandin-D synthase; PDS; PGD2; LPGDS; PGDS2; L-PGDS
• Gene ID: 5730
• mRNA Refseq: NM_000954
• Protein Refseq: NP_000945
• MIM: 176803
• UniProt ID: P41222
• Chromosome Location: 9q34.2-q34.3
• Pathway: Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Eicosanoid Synthesis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Prostaglandin Synthesis and Regulation, organism-specific biosystem; prostanoid biosynthesis, organism-specific biosystem
• Function: binding; fatty acid binding; isomerase activity; prostaglandin-D synthase activity; prostaglandin-D synthase activity; retinoid binding; transporter activity