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Recombinant Human UL16 Binding Protein 1, His-tagged

Cat.No. : ULBP1-7163H
Product Overview : Recombinant human ULBP1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 25 kDa.
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  • Gene Information
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Description : ULBP1 is ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. In CMV infected cells, ULBP1 interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT.
Molecular Mass : 25 kDa (216aa) confirmed by MALDI-TOF
Protein length : 26-216aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSHMGWVDT HCLCYDFIIT PKSRPEPQWC EVQGLVDERP FLHYDCVNHK AKAFASLGKK VNVTKTWEEQ TETLRDVVDF LKGQLLDIQV ENLIPIEPLT LQARMSCEHE AHGHGRGSWQ FLFNGQKFLL FDSNNRKWTA LHPGAKKMTE KWEKNRDVTM FFQKISLGDC KMWLEEFLMY WEQMLDPTKP PSLAPG
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Name : ULBP1 UL16 binding protein 1 [ Homo sapiens ]
Official Symbol : ULBP1
Synonyms : ULBP1; UL16 binding protein 1; NKG2D ligand 1; RAET1I; N2DL-1; NKG2DL1; alcan-beta; UL16-binding protein 1; retinoic acid early transcript 1I;
Gene ID : 80329
mRNA Refseq : NM_025218
Protein Refseq : NP_079494
MIM : 605697
UniProt ID : Q9BZM6
Chromosome Location : 6q25
Pathway : Adaptive Immune System, organism-specific biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem;
Function : MHC class I receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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08/02/2022

    Reducing time requirements, the protein biomolecular reagent simplifies experimental operation.

    01/27/2018

      Capable of detecting low protein concentrations, the substance demonstrates high sensitivity.

      03/04/2017

        Actively listening to user feedback, the manufacturer continuously improves products.

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