Recombinant Human Kallikrein 1, His-tagged
Cat.No. : | KLK1-7198H |
Product Overview : | Recombinant human KLK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 28.7 kDa. |
- Specification
- Gene Information
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Description : | Kallikrein-1, also known as KLK1, belongs to the Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT. |
Molecular Mass : | 28.7 kDa (259aa) confirmed by MALDI-TOF |
Protein length : | 25-262aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MIVGGWECEQ HSQPWQAALY HFSTFQCGGI LVHRQWVLTA AHCISDNYQL WLGRHNLFDD ENTAQFVHVS ESFPHPGFNM SLLENHTRQA DEDYSHDLML LRLTEPADTI TDAVKVVELP TQEPEVGSTC LASGWGSIEP ENFSFPDDLQ CVDLKILPND ECKKVHVQKV TDFMLCVGHL EGGKDTCVGD SGGPLMCDGV LQGVTSWGYV PCGTPNKPSV AVRVLSYVKW IEDTIAENS |
Purity : | >90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25 mg/ml (determined by Bradford assay) |
Gene Name : | KLK1 kallikrein 1 [ Homo sapiens ] |
Official Symbol : | KLK1 |
Synonyms : | KLK1; kallikrein 1; kallikrein 1, renal/pancreas/salivary; kallikrein-1; Klk6; tissue kallikrein; glandular kallikrein 1; kallikrein serine protease 1; kidney/pancreas/salivary gland kallikrein; hK1; KLKR; |
Gene ID : | 3816 |
mRNA Refseq : | NM_002257 |
Protein Refseq : | NP_002248 |
UniProt ID : | P06870 |
Chromosome Location : | 19q13.3 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; |
Function : | peptidase activity; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
KLK1-605H | Recombinant Human KLK1 Protein, GST/His-tagged | +Inquiry |
KLK1-3228H | Recombinant Human KLK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLK1-074H | Recombinant Human KLK1 Protein, His-tagged | +Inquiry |
KLK1-389C | Recombinant Cynomolgus Monkey KLK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLK1-0495H | Recombinant Human KLK1 Protein (I25-S262), His tagged | +Inquiry |
◆ Native Protein | ||
KLK1-29685TH | Native Human KLK1 | +Inquiry |
◆ Lysates | ||
KLK1-2901HCL | Recombinant Human KLK1 cell lysate | +Inquiry |
KLK1-743MCL | Recombinant Mouse KLK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionKLK1 participates in the regulation of blood clotting and fibrinolysis by influencing the activation of certain coagulation factors and promoting fibrinolysis.
KLK1 contributes to renal function by promoting vasodilation in the renal blood vessels and influencing sodium and water excretion, which can be beneficial in kidney diseases.
Some studies suggest that KLK1 may be involved in cancer progression, but the relationship is complex and not fully understood. Further research is needed.
Some studies suggest that KLK1-based therapies may have potential in managing inflammatory conditions, but more research is needed for conclusive evidence.
The potential use of KLK1 in cancer therapy is an area of investigation, but no specific KLK1-based cancer therapies have been established yet.
Customer Reviews (3)
Write a reviewWhether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.
Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.
This strong track record of excellence further attests to the KLK1 protein's capability to meet the rigorous demands of research projects.
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