Recombinant Human Proteasome (prosome, macropain) 26S Subunit, Non-ATPase, 10
Cat.No. : | PSMD10-6927H |
Product Overview : | Recombinant human PSMD10 was expressed in E. coli and purified by conventional chromatography techniques. MW: 24.4 kDa. |
- Specification
- Gene Information
- Related Products
Description : | PSMD10 is an oncoprotein commonly overexpressed in most hepatocellular carcinomas. PSMD10 interacts with S6 ATPase of the 19S regulatory particle of the 26S proteasome. It is known to play a role in the regulation of the phosphorylation of the retinoblastoma protein by CDK4, and to enhance the ubiquitinylation of p53 by MDM2. PSMD10 consists of 7 ankyrin repeats and is structurally similar to I kappa Bs. Recombinant human PSMD10 was expressed in E. coli and purified by conventional chromatography techniques. |
Source : | E. coli |
Species : | Human |
Tag : | N/A |
Form : | Liquid. In Phosphate buffered saline (pH7.4), 10% glycerol |
Molecular Mass : | 24.4 kDa (226aa), confirmed by MALDI-TOF |
Protein length : | 1-226aa |
AA Sequence : | MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG |
Purity : | >95% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [ Homo sapiens ] |
Official Symbol : | PSMD10 |
Synonyms : | PSMD10; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; 26S proteasome non-ATPase regulatory subunit 10; gankyrin; p28; ankyrin repeat protein; 26S proteasome regulatory subunit p28; hepatocellular carcinoma-associated protein p28-II; p28(GANK); dJ889N15.2; |
Gene ID : | 5716 |
mRNA Refseq : | NM_002814 |
Protein Refseq : | NP_002805 |
MIM : | 603480 |
UniProt ID : | O75832 |
Chromosome Location : | Xq22.3 |
Pathway : | APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc20 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem; Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; |
Function : | protein binding; transcription factor binding; |
Products Types
◆ Recombinant Protein | ||
PSMD10-3486R | Recombinant Rhesus Macaque PSMD10 Protein, His (Fc)-Avi-tagged | +Inquiry |
PSMD10-4444R | Recombinant Rat PSMD10 Protein, His (Fc)-Avi-tagged | +Inquiry |
Psmd10-5189M | Recombinant Mouse Psmd10 Protein, Myc/DDK-tagged | +Inquiry |
PSMD10-5240C | Recombinant Chicken PSMD10 | +Inquiry |
PSMD10-1502H | Recombinant Human PSMD10 protein, His & T7-tagged | +Inquiry |
◆ Lysates | ||
PSMD10-2755HCL | Recombinant Human PSMD10 293 Cell Lysate | +Inquiry |
PSMD10-2756HCL | Recombinant Human PSMD10 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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