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Active Recombinant Human GSK3 alpha, GST-tagged

Cat.No. : GSK3A-1411H
Product Overview : Recombinant full-length human GSK3alpha was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
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Description : GSK3α is a multifunctional protein serine kinase, homologous to Drosophila shaggy (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and transcription factors (e.g., JUN). GSK3α also plays a role in the WNT and PI3K signaling pathways. Alzheimer disease is associated with increased production and aggregation of amyloid-beta-40 and -42 peptides into plaques. GSK3α is required for maximal production of the beta-amyloid-40 and -42 peptides generated from the amyloid precursor protein by presenilin-dependent gamma-secretase cleavage. In vitro, lithium, a GSK3α?inhibitor, blocks the production of the beta-amyloid peptides by interfering with the gamma-secretase step.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 184 nmol/min/mg
Molecular Mass : ~81 kDa
Protein length : Full length
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : GSK3A glycogen synthase kinase 3 alpha [ Homo sapiens ]
Official Symbol : GSK3A
Synonyms : GSK3A; glycogen synthase kinase 3 alpha; glycogen synthase kinase-3 alpha; GSK-3 alpha; serine/threonine-protein kinase GSK3A; DKFZp686D0638;
Gene ID : 2931
mRNA Refseq : NM_019884
Protein Refseq : NP_063937
MIM : 606784
UniProt ID : P49840
Chromosome Location : 19q13
Pathway : AKT phosphorylates targets in the cytosol, organism-specific biosystem; Activation of Chaperone Genes by XBP1(S), organism-specific biosystem; Activation of Chaperones by IRE1alpha, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem;
Function : ATP binding; nucleotide binding; protein binding; protein kinase A catalytic subunit binding; protein serine/threonine kinase activity; tau-protein kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In what ways is GSK3A linked to diabetes? 09/27/2021

GSK3A is implicated in insulin signaling and glucose metabolism, and its dysregulation is associated with insulin resistance, a key feature of type 2 diabetes.

Can GSK3A inhibitors have an impact on mood disorders? 11/16/2019

Yes, GSK3A is implicated in pathways associated with mood regulation, and inhibitors are being investigated for their potential in treating mood disorders.

Are there GSK3A modulators being explored for anti-inflammatory therapies? 08/28/2019

Yes, there is ongoing research to develop GSK3A modulators as potential anti-inflammatory agents.

How does GSK3A contribute to inflammatory conditions? 04/25/2017

GSK3A is involved in inflammatory signaling pathways, and its activity is linked to the regulation of inflammatory responses.

Are there any clinical interventions targeting GSK3A for diabetes management? 04/02/2016

Researchers are investigating the potential of GSK3A inhibitors to improve insulin sensitivity and glucose homeostasis in diabetes.

Customer Reviews (3)

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Reviews
08/12/2020

    Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

    09/18/2019

      This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

      04/10/2019

        the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the GSK3A protein.

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