Active Recombinant Human PDE7B, GST-tagged
Cat.No. : | PDE7B-1532H |
Product Overview : | Full-length recombinant human PDE7B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | PDE7B is a cAMP-specific phosphodiesterase and a member of the cyclic nucleotide phosphodiesterase family that catalyzes the hydrolysis of cAMP to the corresponding 5-monophosphate and provides a mechanism to downregulate cAMP signaling. PDE7B is over-expressed in chronic lymphocytic leukemia and inhibition of PDE7B leads to induction of apoptosis. PDE7B has been identified as a candidate gene for measuring treatment response to risperidone and may confer susceptibility to schizophrenia. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 28 nmol/min/mg |
Molecular Mass : | ~73 kDa |
Protein length : | Full length |
Purity : | >80% |
Applications : | PDE Assay |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | PDE7B phosphodiesterase 7B [ Homo sapiens ] |
Official Symbol : | PDE7B |
Synonyms : | PDE7B; phosphodiesterase 7B; cAMP-specific 3,5-cyclic phosphodiesterase 7B; rolipram-insensitive phosphodiesterase type 7; high-affinity cAMP-specific 3,5-cyclic phosphodiesterase; bA472E5.1; MGC88256; |
Gene ID : | 27115 |
mRNA Refseq : | NM_018945 |
Protein Refseq : | NP_061818 |
MIM : | 604645 |
UniProt ID : | Q9NP56 |
Chromosome Location : | 6q23-q24 |
Pathway : | G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Morphine addiction, organism-specific biosystem; Morphine addiction, conserved biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; |
Function : | 3,5-cyclic-AMP phosphodiesterase activity; 3,5-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; |
Products Types
◆ Recombinant Protein | ||
Pde7b-4752M | Recombinant Mouse Pde7b Protein, Myc/DDK-tagged | +Inquiry |
PDE7B-1607H | Recombinant Human PDE7B, His-tagged | +Inquiry |
PDE7B-446H | Recombinant Human Phosphodiesterase 7B, GST-tagged | +Inquiry |
PDE7B-30823TH | Recombinant Human PDE7B | +Inquiry |
PDE7B-30224TH | Recombinant Human PDE7B | +Inquiry |
◆ Lysates | ||
PDE7B-3340HCL | Recombinant Human PDE7B 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1848 | PDE7B Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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