Recombinant Human MGMT, His-tagged
Cat.No. : | MGMT-6958H |
Product Overview : | Recombinant full length human MGMT was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. |
- Specification
- Gene Information
- Related Products
Description : | MGMT or O-6-methylguanine-DNA methyltransferase is the major mutagenic and carcinogenic lesion in DNA induced by simple alkylating mutagens. The methylation of the MGMT promoter in gliomas is a useful predictor of the responsiveness of the tumors to alkylating agents. The clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Methylation of the MGMT promoter in tumors is associated with longer survival in glioblastoma patients. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~25 kDa |
Protein length : | Full length |
Purity : | >95% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1 μg/μ |
Gene Name : | MGMT O-6-methylguanine-DNA methyltransferase [ Homo sapiens ] |
Official Symbol : | MGMT |
Synonyms : | MGMT; O-6-methylguanine-DNA methyltransferase; methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; |
Gene ID : | 4255 |
mRNA Refseq : | NM_002412 |
Protein Refseq : | NP_002403 |
MIM : | 156569 |
UniProt ID : | P16455 |
Chromosome Location : | 10q26 |
Pathway : | DNA Damage Reversal, organism-specific biosystem; DNA Repair, organism-specific biosystem; |
Function : | DNA binding; DNA-methyltransferase activity; calcium ion binding; methylated-DNA-[protein]-cysteine S-methyltransferase activity; methyltransferase activity; transferase activity; |
Products Types
◆ Recombinant Protein | ||
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MGMT-075H | Recombinant Human MGMT Protein, His-tagged | +Inquiry |
◆ Lysates | ||
MGMT-1109HCL | Recombinant Human MGMT cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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