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Recombinant Human SETMAR, GST-tagged

Cat.No. : SETMAR-6966H
Product Overview : Recombinant full-length human SETMAR was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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Description : SETMAR or SET domain and mariner transposase fusion gene is a nonhomologous end-joining repair protein that regulates genomic integration of exogenous DNA by opening chromatin and facilitating joining of DNA ends. SETMAR has histone methyltransferase activity and methylates Lys-4 and Lys-36 of histone H3. SETMAR also has DNA nicking activity and may play a role in DNA repair. Human Pso4 forms a stable complex with SETMAR that regulates Metnase function in DNA repair. SETMAR has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5-terminal inverted repeats (TIRs) of the Hsmar1 element.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~66-69 kDa
Protein length : Full length
Purity : >85%
Applications : Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.2 μg/μl
Gene Name : SETMAR SET domain and mariner transposase fusion gene [ Homo sapiens ]
Official Symbol : SETMAR
Synonyms : SETMAR; SET domain and mariner transposase fusion gene; histone-lysine N-methyltransferase SETMAR; metnase; hsMar1; SET domain and mariner transposase fusion gene-containing protein; METNASE;
Gene ID : 6419
mRNA Refseq : NM_001243723
Protein Refseq : NP_001230652
MIM : 609834
UniProt ID : Q53H47
Chromosome Location : 3p26.2
Pathway : Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function : endonuclease activity; histone-lysine N-methyltransferase activity; hydrolase activity; metal ion binding; methyltransferase activity; protein binding; protein homodimerization activity; structure-specific DNA binding; structure-specific DNA binding; transferase activity; transposase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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