Recombinant Human ELK1, GST-tagged

• Cat.No.: KCNH8-7049H
• Product Overview: Recombinant full-length human ELK1 was expressed in E. coli cells using an N-terminal GST tag.

Specification

• Description: ELK1 is a member of the ETS oncogene family of transcription factors. ELK1 protein interacts with promoter of the c-fos proto-oncogene and has been shown to be involved in the Ras-Raf-MAPK signaling cascade. Immature phosphorylation of transcription factor ELK-1 is implicated in premature aging syndrome and insulin resistance. Expression studies have revealed that elevated expression of ELK1-like protein in human esophageal can result in squamous cell carcinoma.
• Source: E. coli
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~81 kDa
• Protein length: Full length
• Purity: >75%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.2 μg/μl
• Storage Buffer: Sterile distilled water at a concentration of 1mg/ml or less.

Gene Information

• Gene Name: KCNH8 potassium voltage-gated channel, subfamily H (eag-related), member 8 [ Homo sapiens ]
• Official Symbol: KCNH8
• Synonyms: KCNH8; potassium voltage-gated channel, subfamily H (eag-related), member 8; potassium voltage-gated channel subfamily H member 8; elk3; Kv12.1; hElk1; ELK channel 3; ether-a-go-go-like potassium channel 1; ether-a-go-go-like potassium channel 3; voltage-gated potassium channel subunit Kv12.1; ELK; ELK1
• Gene ID: 131096
• mRNA Refseq: NM_144633
• Protein Refseq: NP_653234
• MIM: 608260
• UniProt ID: Q96L42
• Chromosome Location: 3p24.3
• Pathway: Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem
• Function: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; two-component sensor activity; voltage-gated ion channel activity; voltage-gated potassium channel activity