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Recombinant Human HSF1, GST-tagged

Cat.No. : HSF1-7050H
Product Overview : Recombinant full length human HSF1 was expressed in E. coli cells using a N-terminal GST tag.
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  • Gene Information
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Description : HSF1 is a member of the heat shock transcription factor family. Protein-damaging stress lead to the activation of HSF1 which binds to upstream regulatory sequences in the promoters of heat shock genes leading to enhanced heat shock gene expression. The activation of HSF1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications. HSF1 activity is regulated at different levels by heat shock proteins and co-chaperones and is modulated further by a number of mechanisms involving other stress-regulated aspects of cell metabolism.
Source : E. coli
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass : ~96 kDa
Protein length : Full length
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.2μg/μl
Gene Name : HSF1 heat shock transcription factor 1 [ Homo sapiens ]
Official Symbol : HSF1
Synonyms : HSF1; heat shock transcription factor 1; heat shock factor protein 1; HSTF1; HSF 1; HSTF 1;
Gene ID : 3297
mRNA Refseq : NM_005526
Protein Refseq : NP_005517
MIM : 140580
UniProt ID : Q00613
Chromosome Location : 8q24.3
Pathway : Legionellosis, organism-specific biosystem; Legionellosis, conserved biosystem;
Function : protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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In which cellular compartments is HSF1 predominantly localized? 10/06/2022

HSF1 is predominantly localized in the cytoplasm of cells, and it undergoes nuclear translocation upon activation.

What role does HSF1 play in the regulation of protein homeostasis and the heat shock response? 07/14/2022

The role of HSF1 includes regulating protein homeostasis and the heat shock response, ensuring cellular proteostasis.

What diseases or conditions are associated with dysregulation or abnormal expression of HSF1? 11/07/2020

Dysregulation or abnormal expression of HSF1 is associated with conditions such as cancer, neurodegenerative disorders, and metabolic diseases.

How does HSF1 influence cellular processes such as apoptosis and senescence? 06/07/2020

HSF1 influences cellular processes such as apoptosis and senescence, playing a role in cell fate decisions under stress conditions.

What is the primary function of heat shock factor 1 (HSF1) in cellular stress responses? 02/21/2018

Heat shock factor 1 (HSF1) primarily functions in cellular stress responses, orchestrating the heat shock response.

Are there therapeutic implications or potential targets related to HSF1 in diseases involving cellular stress? 12/19/2017

There are potential therapeutic implications related to HSF1 in diseases involving cellular stress, making it a target for drug development.

How does HSF1 become activated in response to cellular stress, and what are its target genes? 07/03/2016

HSF1 becomes activated in response to cellular stress, such as heat shock, and it induces the expression of heat shock proteins.

Customer Reviews (3)

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Reviews
08/30/2021

    The manufacturer's commitment to open science principles resonated with our lab's dedication to transparent research.

    12/17/2018

      We valued the educational webinars and documentation that enhanced our team's proficiency in utilizing the product.

      12/16/2017

        Its association with impactful research publications contributed to its reputation as a valuable scientific tool.

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