Recombinant Human HSF1, GST-tagged
Cat.No. : | HSF1-7050H |
Product Overview : | Recombinant full length human HSF1 was expressed in E. coli cells using a N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | HSF1 is a member of the heat shock transcription factor family. Protein-damaging stress lead to the activation of HSF1 which binds to upstream regulatory sequences in the promoters of heat shock genes leading to enhanced heat shock gene expression. The activation of HSF1 proceeds through a multi-step pathway, involving a monomer-to-trimer transition, nuclear accumulation and extensive posttranslational modifications. HSF1 activity is regulated at different levels by heat shock proteins and co-chaperones and is modulated further by a number of mechanisms involving other stress-regulated aspects of cell metabolism. |
Source : | E. coli |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Molecular Mass : | ~96 kDa |
Protein length : | Full length |
Purity : | >90% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.2μg/μl |
Gene Name : | HSF1 heat shock transcription factor 1 [ Homo sapiens ] |
Official Symbol : | HSF1 |
Synonyms : | HSF1; heat shock transcription factor 1; heat shock factor protein 1; HSTF1; HSF 1; HSTF 1; |
Gene ID : | 3297 |
mRNA Refseq : | NM_005526 |
Protein Refseq : | NP_005517 |
MIM : | 140580 |
UniProt ID : | Q00613 |
Chromosome Location : | 8q24.3 |
Pathway : | Legionellosis, organism-specific biosystem; Legionellosis, conserved biosystem; |
Function : | protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; |
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◆ Lysates | ||
HSF1-339HCL | Recombinant Human HSF1 lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionHSF1 is predominantly localized in the cytoplasm of cells, and it undergoes nuclear translocation upon activation.
The role of HSF1 includes regulating protein homeostasis and the heat shock response, ensuring cellular proteostasis.
Dysregulation or abnormal expression of HSF1 is associated with conditions such as cancer, neurodegenerative disorders, and metabolic diseases.
HSF1 influences cellular processes such as apoptosis and senescence, playing a role in cell fate decisions under stress conditions.
Heat shock factor 1 (HSF1) primarily functions in cellular stress responses, orchestrating the heat shock response.
There are potential therapeutic implications related to HSF1 in diseases involving cellular stress, making it a target for drug development.
HSF1 becomes activated in response to cellular stress, such as heat shock, and it induces the expression of heat shock proteins.
Customer Reviews (3)
Write a reviewThe manufacturer's commitment to open science principles resonated with our lab's dedication to transparent research.
We valued the educational webinars and documentation that enhanced our team's proficiency in utilizing the product.
Its association with impactful research publications contributed to its reputation as a valuable scientific tool.
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