Recombinant Human SLAMF1, His-tagged

• Cat.No.: SLAMF1-7101H
• Product Overview: Recombinant human SLAMF1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: SLAMF1 belongs to the immunoglobulin gene superfamily and is involved in T-cell stimulation. This protein is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. High-affinity for self-ligand is important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol
• Molecular Mass: 26.7kDa (240aa)
• Protein length: 21-237aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSASYGTGG RMMNCPKILR QLGSKVLLPL TYERINKSMN KSIHIVVTMA KSLENSVENK IVSLDPSEAGPPRYLGDRYK FYLENLTLGI RESRKEDEGW YLMTLEKNVS VQRFCLQLRL YEQVSTPEIK VLNKTQENGT CTLILGCTVE KGDHVAYSWS EKAGTHPLNP ANSSHLLSLT LGPQHADNIY ICTVSNPISN NSQTFSPWPG CRTDPSETKP
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml

Gene Information

• Gene Name: SLAMF1 signaling lymphocytic activation molecule family member 1 [ Homo sapiens ]
• Official Symbol: SLAMF1
• Synonyms: SLAMF1; signaling lymphocytic activation molecule family member 1; signaling lymphocytic activation molecule , SLAM; signaling lymphocytic activation molecule; CD150; IPO-3; SLAM; CDw150
• Gene ID: 6504
• mRNA Refseq: NM_003037
• Protein Refseq: NP_003028
• MIM: 603492
• UniProt ID: Q13291
• Chromosome Location: 1q23.3
• Pathway: Measles, organism-specific biosystem; Measles, conserved biosystem
• Function: antigen binding; receptor activity; transmembrane signaling receptor activity