Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

Recombinant Human FURIN, His-tagged

Cat.No. : FURIN-606H
Product Overview : Recombinant human Furin is a 61.7 kDa protein, corresponding to residues 124 through 715 of the Furin precursor plus a C-terminal His tag.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : FURIN-606H
Description : Proteases (also called Proteolytic Enzymes, Peptidases, or Proteinases) are enzymes that hydrolyze the amide bonds within proteins or peptides. Most proteases act in a specific manner, hydrolyzing bonds at or adjacent to specific residues or a specific sequence of residues contained within the substrate protein or peptide. Proteases play an important role in most diseases and biological processes including prenatal and postnatal development, reproduction, signal transduction, the immune response, various autoimmune and degenerative diseases, and cancer. They are also an important research tool, frequently used in the analysis and production of proteins. Furin is a calcium dependent serine endoprotease that processes numerous proproteins of different secretory pathways into their mature forms by cleaving at the carboxyl side of the recognition sequence, R-Xaa-(K/R)-R, where Xaa can be any amino acid.
Source : Hi-5 Insect cells
AASequece : DLNVKAAWAQ GYTGHGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC TESHTGTSAS APLAAGIIAL TLEANKNLTW RDMQHLVVQT SKPAHLNAND WATNGVGRKV SHSYGYGLLD AGAMVALAQN WTTVAPQRKI IDILTEPKDI GKRLEVRKTV TACLGEPNHI TRLEHAQARL TLSYNRRGDL AIHLVSPMGT RSTLLAARPH DYSADGFNDW AFMTTHSWDE DPSGEWVLEI ENTSEANNYG TLTKFTLVLY GTAPEGLPVP PESSGCKTLT SSQACVVCEE GFSLHQKSCV QHCPPGFAPQ VLDTHYSTEN DVETIRASVC APCHACSATC QGPALTDCLS CPSHASLDPV EQTCSRQSQS SRESPPQQQP PRLPPEVEAG QRLRAGLLPS HLPEHHHHHH HH
Purity : Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity : Measured by its ability to cleave the fluorogenic peptide substrate Boc-Arg-Val-Arg-Arg-AMC.
OfficialSymbol : FURIN
Gene Name : FURIN furin (paired basic amino acid cleaving enzyme) [ Homo sapiens ]
Synonyms : FURIN; furin (paired basic amino acid cleaving enzyme); FUR; PACE; SPC1; PCSK3; paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)
Gene ID : 5045
mRNA Refseq : NM_002569
Protein Refseq : NP_002560
MIM : 136950
UniProt ID : P09958
Chromosome Location : 15q26.1
Pathway : Activation of Matrix Metalloproteinases; Degradation of the extracellular matrix; Delta-Notch Signaling Pathway; Developmental Biology; Extracellular matrix organization; Gamma-carboxylation, transport, and amino-terminal cleavage of proteins; Glypican 3 network; HIF-1-alpha transcription factor network; Influenza A; Metabolism of proteins; NGF processing; Notch signaling pathway; PTM: gamma carboxylation, hypusine formation and arylsulfatase activation; Post-translational protein modification; Pre-NOTCH Expression and Processing
Function : endopeptidase activity; metal ion binding; nerve growth factor binding; peptidase activity; peptide binding; protease binding; serine-type endopeptidase activity; serine-type endopeptidase inhibitor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (3)

Write a review
Reviews
10/10/2022

    The proteins purchased from your company are of very high quality and are suitable for WB experiments.

    02/04/2022

      High quality product at a good price, a satisfactory shopping experience.

      03/30/2021

        The staff were enthusiastic and proactive in communicating with me and solving many technical problems in a timely manner.

        Ask a Question for All FURIN Products

        Required fields are marked with *

        My Review for All FURIN Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends