Recombinant Human PRG4, GST-tagged
Cat.No. : | PRG4-1501H |
Product Overview : | Recombinant Human PRG4 encoding (1305 a.a. - 1404 a.a.), fused a GST-tag at N-terminal, was expressed in Wheat germ. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PRG4-1501H |
Description : | The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | Wheat Germ |
Molecular Mass : | 36.74 kDa |
Purity : | Glutathione Sepharose 4 Fast Flow |
Applications : | WB |
Sequence : | ERAIGPSQTHTIRIQYSPARLAYQD KGVLHNEVKVSILWRGLPNVVTSAI SLPNIRKPDGYDYYAFSKDQYYNID VPSRTARAITTRSGQTLSKVWYNCP |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Note : | Best use within three months from the date of receipt of this protein. |
OfficialSymbol : | PRG4 |
Gene Name : | PRG4 proteoglycan 4 [ Homo sapiens ] |
Synonyms : | PRG4; proteoglycan 4; MSF; SZP; CACP; HAPO; JCAP; FLJ32635; bG174L6.2; lubricin; OTTHUMP00000033580; megakaryocyte stimulating factor; articular superficial zone protein; bG174L6.2 (MSF: megakaryocyte stimulating factor ); proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome); Megakaryocyte-stimulating factor; Superficial zone proteoglycan; Proteoglycan 4 C-terminal part |
Gene ID : | 10216 |
mRNA Refseq : | NM_005807 |
Protein Refseq : | NP_005798 |
MIM : | 604283 |
UniProt ID : | Q92954 |
Chromosome Location : | 1q25-q31 |
Function : | polysaccharide binding; protein binding; scavenger receptor activity |
Products Types
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionResearch is ongoing, but PRG4 is being investigated as a potential treatment for osteoarthritis due to its role in joint lubrication.
PRG4 provides lubrication to joints, reducing friction between cartilage surfaces and helping to maintain joint health and function.
It may have the potential to slow down joint degeneration by improving joint lubrication, but more research is needed to confirm its preventive effects.
PRG4 protein has several clinical applications, particularly in the field of orthopedics and rheumatology.
Yes, there are clinical trials exploring the use of PRG4 in the treatment of joint-related disorders.
Customer Reviews (3)
Write a reviewWith the PRG4 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.
the PRG4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.
Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.
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