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Recombinant Human PRG4, GST-tagged

Cat.No. : PRG4-1501H
Product Overview : Recombinant Human PRG4 encoding (1305 a.a. - 1404 a.a.), fused a GST-tag at N-terminal, was expressed in Wheat germ.
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  • Gene Information
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Cat. No. : PRG4-1501H
Description : The protein encoded by this gene is a large proteoglycan specifically synthesized by chondrocytes located at the surface of articular cartilage, and also by some synovial lining cells. This protein contains both chondroitin sulfate and keratan sulfate glycosaminoglycans. It functions as a boundary lubricant at the cartilage surface and contributes to the elastic absorption and energy dissipation of synovial fluid. Mutations in this gene result in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : Wheat Germ
Molecular Mass : 36.74 kDa
Purity : Glutathione Sepharose 4 Fast Flow
Applications : WB
Sequence : ERAIGPSQTHTIRIQYSPARLAYQD KGVLHNEVKVSILWRGLPNVVTSAI SLPNIRKPDGYDYYAFSKDQYYNID VPSRTARAITTRSGQTLSKVWYNCP
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note : Best use within three months from the date of receipt of this protein.
OfficialSymbol : PRG4
Gene Name : PRG4 proteoglycan 4 [ Homo sapiens ]
Synonyms : PRG4; proteoglycan 4; MSF; SZP; CACP; HAPO; JCAP; FLJ32635; bG174L6.2; lubricin; OTTHUMP00000033580; megakaryocyte stimulating factor; articular superficial zone protein; bG174L6.2 (MSF: megakaryocyte stimulating factor ); proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome); Megakaryocyte-stimulating factor; Superficial zone proteoglycan; Proteoglycan 4 C-terminal part
Gene ID : 10216
mRNA Refseq : NM_005807
Protein Refseq : NP_005798
MIM : 604283
UniProt ID : Q92954
Chromosome Location : 1q25-q31
Function : polysaccharide binding; protein binding; scavenger receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can PRG4 be used as a treatment for osteoarthritis? 10/21/2022

Research is ongoing, but PRG4 is being investigated as a potential treatment for osteoarthritis due to its role in joint lubrication.

How does PRG4 contribute to joint health? 08/19/2022

PRG4 provides lubrication to joints, reducing friction between cartilage surfaces and helping to maintain joint health and function.

Can PRG4 be used to prevent joint degeneration? 03/01/2022

It may have the potential to slow down joint degeneration by improving joint lubrication, but more research is needed to confirm its preventive effects.

What are the clinical applications of PRG4 protein? 07/16/2016

PRG4 protein has several clinical applications, particularly in the field of orthopedics and rheumatology.

Are there any clinical trials involving PRG4 protein? 05/22/2016

Yes, there are clinical trials exploring the use of PRG4 in the treatment of joint-related disorders.

Customer Reviews (3)

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Reviews
01/26/2023

    With the PRG4 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.

    02/12/2021

      the PRG4 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.

      08/22/2018

        Its versatility and reliability make it a great asset in the pursuit of scientific discoveries.

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