Recombinant Human CTLA4, His-tagged
Cat.No. : | CTLA4-7259H |
- Specification
- Gene Information
- Related Products
product overview : | Recombinant human CTLA4 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
description : | CTLA4 is a member of the immunoglobulin superfamily and transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
source : | E. coli |
species : | Human |
tag : | His |
form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol |
molecular mass : | 15.9 kDa (149aa) |
protein length : | 36-161aa |
aa sequence : | MGSSHHHHHH SSGLVPRGSH MGSKAMHVAQ PAVVLASSRG IASFVCEYAS PGKATEVRVT VLRQADSQVT EVCAATYMMG NELTFLDDSICTGTSSGNQV NLTIQGLRAM DTGLYICKVE LMYPPPYYLG IGNGTQIYVI DPEPCPDSD |
purity : | >90% by SDS - PAGE |
applications : | SDS-PAGE |
storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
concentration : | 1 mg/ml |
gene name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ] |
official symbol : | CTLA4 |
synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; GRD4; CTLA-4; IDDM12; CELIAC3; |
Gene ID : | 1493 |
mrna refseq : | NM_001037631 |
protein refseq : | NP_001032720 |
uniprot id : | P16410 |
chromosome location : | 2q33 |
pathway : | Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; |
function : | protein binding; |
Products Types
◆ Recombinant Protein | ||
CTLA4-655M | Recombinant Mouse CTLA4 Protein, IgG2a Fc-tagged | +Inquiry |
CTLA4-2073P | Recombinant CTLA4 Protein, His-Flag-StrepII-tagged | +Inquiry |
Ctla4-158M | Recombinant Mouse Ctla4 Protein, His (Fc)-Avi-tagged | +Inquiry |
CTLA4-902R | Recombinant Rhesus Macaque CTLA4 Protein, His (Fc)-Avi-tagged | +Inquiry |
CTLA4-3229H | Recombinant Human CTLA4 protein(Met1-Phe162), rFc-tagged | +Inquiry |
◆ Lysates | ||
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
CTLA4-1047CCL | Recombinant Cynomolgus CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1712 | CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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