|
Cat.No.
|
CAB-1817MH
|
|
Product Overview
|
Mouse Anti-CDK7 Monoclonal Antibody
|
|
Antigen Description
|
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
|
|
specificity
|
Reacts primarily with the human U1A protein and has minor cross-reactivity with the U2B” protein,contained in the U1 and U2 small nuclear ribonucleoprotein (snRNP) complexes.
|
|
Target
|
CDK7
|
|
Immunogen
|
Recombinant beta-galactosidase U2B fusion protein.
|
|
Host
|
Mouse
|
|
Isotype
|
IgG1
|
|
Source
|
Cell culture
|
|
Species
|
Human
|
|
Clone
|
NO-1.2
|
|
conjugation
|
N/A
|
|
Applications
|
WB,IFA,IP
|
|
Format
|
Supernatant, Lyophilized. Reconstitute in 1ml distilled water
|
|
Buffer
|
Lyophilized from PBS containing 1% BSA
|
|
Storage
|
Store lyophilized product at 2–8°C. After reconstitution, aliquot and store at -20°C. Avoid multiple freeze/thaw cycles.
|
|
Preservative
|
0.1% Sodium Azide
|
|
Warning
|
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
|
|
Antigen Gene Information
|
|
Gene Name
|
CDK7 cyclin-dependent kinase 7 [ Homo sapiens ]
|
|
Official Symbol
|
CDK7
|
|
Synonyms
|
CDK7; cyclin-dependent kinase 7; cyclin dependent kinase 7 (homolog of Xenopus MO15 cdk activating kinase) , cyclin dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk activating kinase); CAK; CAK1; CDKN7; MO15; STK1; p39 Mo15; protein kinase; 39 KDa protein kinase; kinase subunit of CAK; CDK-activating kinase 1; serine/threonine kinase stk1; cell division protein kinase 7; serine/threonine protein kinase 1; serine/threonine-protein kinase 1; serine/threonine protein kinase MO15; homolog of Xenopus MO15 Cdk-activating kinase; TFIIH basal transcription factor complex kinase subunit; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); HCAK; p39MO15;
|
|
GeneID
|
1022
|
|
mRNA Refseq
|
NM_001799
|
|
Protein Refseq
|
NP_001790
|
|
MIM
|
601955
|
|
UniProt ID
|
P50613
|
|
Chromosome Location
|
5q12.1
|
|
Pathway
|
Androgen Receptor Signaling Pathway, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem;
|
|
Function
|
ATP binding; DNA-dependent ATPase activity; RNA polymerase II carboxy-terminal domain kinase activity; androgen receptor binding; cyclin-dependent protein kinase activity; nucleotide binding; protein C-terminus binding; protein complex binding; protein kinase activity; transcription coactivator activity;
|
|
|
|
Download Datasheet:
|
|