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Cat.No.
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CAB-1798HH
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Product Overview
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Hamster Anti-EMR3 Monoclonal Antibody
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Antigen Description
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This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.
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specificity
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Recognizes human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 (EMR3), which is a 56 kDa member of the EGF-7 transmembrane (TM7) family of adhesion receptors. EMR3 is expressed at the cell surface as a heterodimer.
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Target
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EMR3
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Immunogen
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ARHO-EMR3-CD97 (EGF1) transfectants
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Host
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Hamster
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Isotype
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IgG
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Source
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Culture
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Species
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Human
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Clone
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C232M
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Affinity Constant
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Not determined
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Purification
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>90 % pure (SDS-PAGE). Protein A chromatography
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conjugation
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N/A
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Applications
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Flow Cyt,IP
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Format
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Purified, Liquid
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Concentration
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Lot specificLot specific
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Buffer
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PBS, pH 7.4
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Storage
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Short term store at 2-8°C. Long term, aliquot and store at -20°C. Prepare working dilution only prior to immediate use. Avoid multiple freeze/thaw cycles. Should this product contain a precipitate, we recommend microcentrifugation before use.
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Preservative
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0.09 % Sodium azide
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Warning
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This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1–1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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Antigen Gene Information
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Gene Name
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EMR3 egf-like module containing, mucin-like, hormone receptor-like 3 [ Homo sapiens ]
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Official Symbol
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EMR3
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Synonyms
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EMR3; egf-like module containing, mucin-like, hormone receptor-like 3; EGF-like module-containing mucin-like hormone receptor-like 3; EGF-like module receptor 3; egf-like module-containing mucin-like receptor 3;
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GeneID
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84658
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mRNA Refseq
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NM_032571
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Protein Refseq
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NP_115960
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MIM
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606101
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UniProt ID
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Q9BY15
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Chromosome Location
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19p13.1
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Pathway
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Class B/2 (Secretin family receptors), organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem;
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Function
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G-protein coupled receptor activity; calcium ion binding; receptor activity; signal transducer activity;
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