|
Cat.No.
|
CAB-2508RH
|
|
Product Overview
|
Rabbit Anti-ERBB2 Monoclonal Antibody
|
|
Antigen Description
|
The ERBB2 gene encodes a member of the tyrosine protein kinase superfamily that is an essential component of a neuregulin-receptor complex called c-erbB2, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. CerbB2 is not activated by EGF, TGF-alpha and amphiregulin. Defects in ERBB2 are associated with gastric cancer, familial glioma of brain, ovarian cancer and lung cancer. C-erbB2 is a single-pass type I membrane protein.
|
|
Target
|
ERBB2
|
|
Immunogen
|
This monoclonal antibody was produced by repeated immunizations with a recombinant protein corresponding to amino acid residues encoding the extracellular domain ofERBB2. The hybridoma was produced by fusing New Zealand White rabbit splenocytes and myeloma cells using conventional technology.
|
|
Host
|
Rabbit
|
|
Species
|
Human
|
|
Clone
|
MARL031.
|
|
conjugation
|
N/A
|
|
Applications
|
ELISA,WB,IHC
|
|
Format
|
Liquid (sterile filtered)
|
|
Storage
|
Store vial at -20°C prior to opening. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing.
|
|
Preservative
|
0.1% (w/v) Sodium Azide
|
|
Antigen Gene Information
|
|
Gene Name
|
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [ Homo sapiens ]
|
|
Official Symbol
|
ERBB2
|
|
Synonyms
|
ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-protein kinase erbB-2; CD340; HER 2; HER2; NEU; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); NGL; TKR1; HER-2; MLN 19; HER-2/neu;
|
|
GeneID
|
2064
|
|
mRNA Refseq
|
NM_001005862
|
|
Protein Refseq
|
NP_001005862
|
|
MIM
|
164870
|
|
UniProt ID
|
P04626
|
|
Chromosome Location
|
17q11.2-q12
|
|
Pathway
|
Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Axon guidance, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Calcium signaling pathway, organism-specific biosystem;
|
|
Function
|
ATP binding; ErbB-3 class receptor binding; Hsp90 protein binding; RNA polymerase I core binding; epidermal growth factor-activated receptor activity; glycoprotein binding; contributes_to growth factor binding; identical protein binding; nucleotide binding; protein C-terminus binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein heterodimerization activity; protein heterodimerization activity; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine kinase activity; protein tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; transmembrane signaling receptor activity; ubiquitin protein ligase binding;
|
|
|
|
Download Datasheet:
|
|