Catalog # or name ...
Rat Anti-Cd209a Monoclonal Antibody
DC-SIGN is a C-type lectin receptor present on both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds to mannose type carbohydrates, a class of Pathogen associated molecular patterns PAMPs commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens.
Recognizes mouse SIGN-R1, a C-type lectin that has been identified as a murine homologue of the human CD-SIGN related molecule, L-SIGN. Mouse SIGN-R1 is specifically expressed on marginal zone macrophages in the spleen, medullary and subcapsular sinus macrophages in the lymph nodes, and at lower levels on liver sinusoidal endothelial cells. SIGN-R1 has not been detected on murine dendritic cell populations. ER-TR9 blocks the uptake of neutral polysaccharides by macrophages.
Isolated C3H thymic stromal cells
Ammonium Sulphate precipitation
PBS, pH 7.4
Store at 2 - 8°C. DO NOT FREEZE!
0.09% Sodium azide
This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 – 1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Antigen Gene Information
Cd209a CD209a antigen [ Mus musculus ]
CD209A; CD209a antigen; CD209 antigen-like protein A; dendritic cell-specific ICAM-3-grabbing non-integrin; CIRE; CD209; CDSIGN; Dcsign; SIGNR5; DC-SIGN; SIGN-R1; DC-SIGN1; MGC130443;
Measles, organism-specific biosystem; Measles, conserved biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem;
binding; mannose binding; metal ion binding; receptor activity; sugar binding;
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