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Cat.No.
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CAB-2228RM
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Product Overview
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Rat Anti-Cd209a Monoclonal Antibody
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Antigen Description
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DC-SIGN is a C-type lectin receptor present on both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds to mannose type carbohydrates, a class of Pathogen associated molecular patterns PAMPs commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens.
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specificity
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Recognizes mouse SIGN-R1, a C-type lectin that has been identified as a murine homologue of the human CD-SIGN related molecule, L-SIGN. Mouse SIGN-R1 is specifically expressed on marginal zone macrophages in the spleen, medullary and subcapsular sinus macrophages in the lymph nodes, and at lower levels on liver sinusoidal endothelial cells. SIGN-R1 has not been detected on murine dendritic cell populations. ER-TR9 blocks the uptake of neutral polysaccharides by macrophages.
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Target
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Cd209a
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Immunogen
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Isolated C3H thymic stromal cells
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Host
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Rat
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Isotype
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IgM
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Source
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Culture
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Species
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Mouse
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Clone
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FR-TR9
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Affinity Constant
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Not determined
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Purification
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Ammonium Sulphate precipitation
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conjugation
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N/A
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Applications
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Flow Cyt,IHC
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Format
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Purified, Liquid
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Concentration
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1mg/ml1mg/ml
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Buffer
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PBS, pH 7.4
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Storage
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Store at 2 - 8°C. DO NOT FREEZE!
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Preservative
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0.09% Sodium azide
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Warning
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This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 – 1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
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Antigen Gene Information
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Gene Name
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Cd209a CD209a antigen [ Mus musculus ]
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Official Symbol
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Cd209a
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Synonyms
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CD209A; CD209a antigen; CD209 antigen-like protein A; dendritic cell-specific ICAM-3-grabbing non-integrin; CIRE; CD209; CDSIGN; Dcsign; SIGNR5; DC-SIGN; SIGN-R1; DC-SIGN1; MGC130443;
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GeneID
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170786
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mRNA Refseq
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NM_133238
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Protein Refseq
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NP_573501
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Pathway
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Measles, organism-specific biosystem; Measles, conserved biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem;
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Function
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binding; mannose binding; metal ion binding; receptor activity; sugar binding;
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Download Datasheet:
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