Recombinant Human MYC, His-tagged
Cat.No. : | MYC-1029H |
Product Overview : | Recombinant humanMYC full-length protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by nickel NTA affinity chromatography. |
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- Gene Information
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Cat. No. : | MYC-1029H |
Description : | c-Myc is a conserved cellular gene. The gene product is anuclear-bound 62,000 molecular weight phosphoprotein (p62c-myc). The nuclear p62c-myc content increased with DNA synthesis in tumors and mucosa. |
Source : | E. coli. |
Formulation : | 50 μg recombinant protein in Renaturation buffer ( 20 mM Tris-HCl , 150 mM NaCl, 1 mM EDTA, 5 mM Glutathione,0.5 mM GSSH and 10% Glycerol), lyophilized.Reconstitute the contents using sterile water no less than 100 μg/ml. |
Molecular weight : | 62 kDa |
Purity : | > 90% by SDS PAGE and coomassie blue staining. |
Usage : | It can be used for WB, ELISA. |
Storage : | Upon receiving, the proteins can be stored at 4°C. After reconstitution,store the working aliquots at -80°C. Avoid repeated freeze and thaw. |
Gene Name : | MYC v-myc myelocytomatosis viral oncogene homolog (avian) [ Homo sapiens ] |
Synonyms : | MYC; v-myc myelocytomatosis viral oncogene homolog (avian); MRTL; c-Myc; bHLHe39; avian myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor |
Gene ID : | 4609 |
mRNA Refseq : | NM_002467 |
Protein Refseq : | NP_002458 |
MIM : | 190080 |
UniProt ID : | P01106 |
Chromosome Location : | 8q24 |
Pathway : | Acute myeloid leukemia; Bladder cancer; Chronic myeloid leukemia; Colorectal cancer; ErbB signaling pathway; Colorectal cancer; Jak-STAT signaling pathway; MAPK signaling pathway; Pathways in cancer; Small cell lung cancer; Small cell lung cancer; Thyroid cancer; Wnt signaling pathway |
Function : | protein binding; transcription factor activity |
Products Types
◆ Recombinant Protein | ||
MYC-060H | Recombinant Human MYC Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
MYC-5787H | Recombinant Human MYC Protein, GST-tagged | +Inquiry |
Myc-4239M | Recombinant Mouse Myc Protein, Myc/DDK-tagged | +Inquiry |
MYC-32H | Recombinant Active Human c-Myc Protein (1-454) | +Inquiry |
MYC-3498R | Recombinant Rat MYC Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MYC-4039HCL | Recombinant Human MYC 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1785 | Myc Reporter Kit (Myc Signaling Pathway) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAbnormal expression of MYC gene may affect the occurrence and progression of cardiovascular diseases such as atherosclerosis by regulating the proliferation of vascular smooth muscle cells and increasing the expression of endothelial cell-specific shear-related proteins.
Because of its important promotion role in pancreatic cancer, MYC gene is regarded as one of the potential targets and drug treatment directions for pancreatic cancer treatment, but specific research and related drugs need to be further verified.
The MYC gene may affect the proliferation of somatic cells by regulating cell cycle progression, such as increasing the S-phase entry of the cell cycle and promoting the G1/S phase transition.
Overexpression and defect of MYC in gastric cancer are associated with the occurrence, progression and prognosis of gastric cancer. MYC translocation and high expression predict a poor prognosis.
MYC gene may be involved in the proliferation and differentiation of hematopoietic stem cells, but the specific mechanism and role still need to be further elucidated.
Abnormal expression of MYC gene may affect tumor progression and prognosis by activating cell cycle constants, apoptosis inhibition, and enhanced cell mobility.
Customer Reviews (3)
Write a reviewThe reproducibility of MYC is very good, and the results remain consistent even after repeated experiments several times, which gives me more confidence in the experimental results.
Stability of this protein was still very good when different chemicals or drugs were added, indicating its excellent anti-interference ability and stability.
Due to stability of MYC in Western blot was very good and even prolonged storage did not affect its performance.
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