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Recombinant Human MYC, His-tagged

Cat.No. : MYC-1029H
Product Overview : Recombinant humanMYC full-length protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by nickel NTA affinity chromatography.
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Cat. No. : MYC-1029H
Description : c-Myc is a conserved cellular gene. The gene product is anuclear-bound 62,000 molecular weight phosphoprotein (p62c-myc). The nuclear p62c-myc content increased with DNA synthesis in tumors and mucosa.
Source : E. coli.
Formulation : 50 μg recombinant protein in Renaturation buffer ( 20 mM Tris-HCl , 150 mM NaCl, 1 mM EDTA, 5 mM Glutathione,0.5 mM GSSH and 10% Glycerol), lyophilized.Reconstitute the contents using sterile water no less than 100 μg/ml.
Molecular weight : 62 kDa
Purity : > 90% by SDS PAGE and coomassie blue staining.
Usage : It can be used for WB, ELISA.
Storage : Upon receiving, the proteins can be stored at 4°C. After reconstitution,store the working aliquots at -80°C. Avoid repeated freeze and thaw.
Gene Name : MYC v-myc myelocytomatosis viral oncogene homolog (avian) [ Homo sapiens ]
Synonyms : MYC; v-myc myelocytomatosis viral oncogene homolog (avian); MRTL; c-Myc; bHLHe39; avian myelocytomatosis viral oncogene homolog; v-myc avian myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor
Gene ID : 4609
mRNA Refseq : NM_002467
Protein Refseq : NP_002458
MIM : 190080
UniProt ID : P01106
Chromosome Location : 8q24
Pathway : Acute myeloid leukemia; Bladder cancer; Chronic myeloid leukemia; Colorectal cancer; ErbB signaling pathway; Colorectal cancer; Jak-STAT signaling pathway; MAPK signaling pathway; Pathways in cancer; Small cell lung cancer; Small cell lung cancer; Thyroid cancer; Wnt signaling pathway
Function : protein binding; transcription factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does overexpression of the MYC gene affect cardiovascular disease? 11/14/2022

Abnormal expression of MYC gene may affect the occurrence and progression of cardiovascular diseases such as atherosclerosis by regulating the proliferation of vascular smooth muscle cells and increasing the expression of endothelial cell-specific shear-related proteins.

Is the MYC gene a potential target for pancreatic cancer or drug therapy? 06/18/2022

Because of its important promotion role in pancreatic cancer, MYC gene is regarded as one of the potential targets and drug treatment directions for pancreatic cancer treatment, but specific research and related drugs need to be further verified.

How does the MYC gene regulate somatic cell proliferation through cell cycle progression? 05/13/2021

The MYC gene may affect the proliferation of somatic cells by regulating cell cycle progression, such as increasing the S-phase entry of the cell cycle and promoting the G1/S phase transition.

What is the role of the MYC gene in stomach cancer? 03/20/2021

Overexpression and defect of MYC in gastric cancer are associated with the occurrence, progression and prognosis of gastric cancer. MYC translocation and high expression predict a poor prognosis.

Is the MYC gene associated with hematopoietic stem cells? 07/10/2020

MYC gene may be involved in the proliferation and differentiation of hematopoietic stem cells, but the specific mechanism and role still need to be further elucidated.

How does abnormal expression of the MYC gene affect tumor progression? 10/30/2019

Abnormal expression of MYC gene may affect tumor progression and prognosis by activating cell cycle constants, apoptosis inhibition, and enhanced cell mobility.

Customer Reviews (3)

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05/19/2022

    The reproducibility of MYC is very good, and the results remain consistent even after repeated experiments several times, which gives me more confidence in the experimental results.

    01/18/2020

      Stability of this protein was still very good when different chemicals or drugs were added, indicating its excellent anti-interference ability and stability.

      10/06/2019

        Due to stability of MYC in Western blot was very good and even prolonged storage did not affect its performance.

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