Catalog # or name ...
Rabbit Anti-NANOG Polyclonal Antibody
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes By similarity. Acts as a transcriptional activator or repressor By similarity. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3" or 5, -[CG][GA][CG]C[GC]ATTAN[GC]-3" By similarity. When overexpressed, promotes cells to enter into S phase.
The antibody detects endogenous level of total Nanog protein.
Peptide sequence around aa. 137~141 (K-Q-V-K-T) derived from Nanog.
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCI, 0.02% sodium azide and 50% glycerol.
Store at -20°C/1 year
Antigen Gene Information
NANOG Nanog homeobox [ Homo sapiens ]
NANOG; Nanog homeobox; homeobox protein NANOG; FLJ12581; FLJ40451; hNanog; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48;
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem;
DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;
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