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Recombinant Human Neurotrophin 3

Cat.No. : NTF3-3621H
Product Overview : Recombinant Human proNT-3 produced in E.coli is a single, non-glycosylated, polypeptide chain containing 239 amino acids and having a molecular mass of 27.4 kDa.
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Cat. No. : NTF3-3621H
Description : The precursor form of neurotrophin-3 (proNT-3) functions via p75NTR and sortilin and induces neuronal apoptosis. On the contrary, mature NT-3 interacts with Trk receptors and selectively promotes the survival, growth and differentiation of neurons. As axon retrograde transport is crucial for neurotrophin signaling, proNT-3 also plays an important role in the mechanism of retrograde signaling.
Biological Activity : As measured by its binding ability in a functional ELISA, immobilized rHuIL-1F10 at 1 μg/ml (100 μl/well) can bind rHuIL-1 Rrp2/Fc Chimera with a linear range of 0.15~5 μg/ml.
Purity : Greater than 95% as determined by (a) Analysis by RP-HPLC; (b) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
Amino-Acid Sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Asn-Asn-Met-Asp-Gln.
Endotoxin : Less than 0.1ng/μg (1.0EU/μg) of rHuproNT-3 as determined by LAL test.
Form : The protein was lyophilized from a concentrated (1mg/ml) solution in 20mM PB, pH 8.0, 300mM NaCl buffer.
Reconstitution : It is recommended to reconstitute the lyophilized rHuproNT-3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage : Lyophilized rHuproNT-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution rHuproNT-3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Gene Name : NTF3 neurotrophin 3 [ Homo sapiens ]
Official Symbol : NTF3
Synonyms : NTF3; NT3; HDNF; NGF2; NGF-2; MGC129711; NT-3; OTTHUMP00000239132; OTTHUMP00000239133; neurotrophic factor; nerve growth factor 2; neurotrophin 3; Nerve growth factor 2; Neurotrophic factor; neurotrophin-3
Gene ID : 4908
mRNA Refseq : NM_002527
Protein Refseq : NP_002518
MIM : 162660
UniProt ID : P20783
Chromosome Location : 12p13
Function : growth factor activity; nerve growth factor binding; neurotrophin receptor binding; protein binding; receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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