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Recombinant Human HDAC2, His-tagged

Cat.No. : HDAC2-3565H
Product Overview : Recombinant human HDAC2 protein, fused to His-tag at C-terminus, was expressed in high-5 cells using baculovirus expression system and purified by using conventional chromatography techniques (1-488aa).
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Cat. No. : HDAC2-3565H
Description : HDAC2 belongs to the histone deacetylase family that act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones. It forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. It also plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Form : Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT, 0.1mM PMSF
Molecular Mass : 56.4 kDa (496aa)
Purity : > 85 % by SDS-PAGE
Concentration : 0.25 mg/ml (determined by Bradford assay )
Sequences of amino acids : MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT KSEQLSNPSR HHHHHH
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°Cor -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : HDAC2 histone deacetylase 2 [ Homo sapiens ]
Official Symbol : HDAC2
Synonyms : HDAC2; RPD3; YAF1; histone deacetylase 2; Histone deacetylase 2; OTTHUMP00000017046; YY1-associated factor 1; transcriptional regulator homolog RPD3; EC 3.5.1.98; HD2
Gene ID : 3066
mRNA Refseq : NM_001527
Protein Refseq : NP_001518
MIM : 605164
UniProt ID : Q92769
Chromosome Location : 6q21
Function : enzyme binding; histone deacetylase activity; hydrolase activity; specific transcriptional repressor activity; transcription activator activity; transcription factor activity; transcription factor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can HDAC2 be a potential biomarker for certain diseases? 08/13/2022

Research suggests that HDAC2 levels can serve as a biomarker for certain diseases, aiding in diagnosis and prognosis.

Are there HDAC inhibitors used in clinical settings? 07/16/2022

Yes, HDAC inhibitors are being explored as a therapeutic strategy in cancer treatment, aiming to block the activity of HDAC2.

How does HDAC2 impact cancer progression? 06/24/2021

HDAC2 is often overexpressed in cancer cells, contributing to uncontrolled cell growth and survival.

How does HDAC2 influence cellular processes through histone deacetylation? 07/27/2018

HDAC2 removes acetyl groups from histones, leading to chromatin condensation and repression of gene transcription, affecting cellular processes.

How does HDAC2 relate to neurodegenerative disorders? 10/23/2016

HDAC2 dysregulation has been observed in neurodegenerative diseases, suggesting a role in the pathogenesis of conditions like Alzheimer's.

Customer Reviews (3)

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Reviews
11/23/2021

    Its versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.

    11/16/2018

      This adaptability ensures that the HDAC2 protein can effectively address my specific research objectives, enabling breakthrough discoveries.

      08/22/2018

        the HDAC2 protein exhibits superior performance across a range of experimental applications.

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