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Cat.No.
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CAB-550MH
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Product Overview
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Mouse Anti-HAX1 Monoclonal Antibody
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Antigen Description
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HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1 (HS1), one of the substrates of receptor-coupled tyrosine kinases activated during clonal expansion and deletion in lymphoid cells. It also interacts with the product of the polycystic kidney disease 2 (PKD2) gene and with the F-actin-binding protein, cortactin. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.
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Target
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HAX1
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Immunogen
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Recombinant human HAX1 (1-279aa) purified from E. coli.
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Host
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Mouse
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Isotype
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Mouse IgG2b heavy chain and k light chain.
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Species
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Human
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Clone
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MAFB4268
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conjugation
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N/A
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Applications
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ELISA,WB
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Format
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Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.
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Concentration
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1mg/ml.1mg/ml.
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Storage
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Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
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Antigen Gene Information
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Gene Name
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HAX1 HCLS1 associated protein X-1 [ Homo sapiens ]
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Official Symbol
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HAX1
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Synonyms
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HAX1; HCLS1 associated protein X-1; HCLS1-associated protein X-1; HCLS1 (and PKD2) associated protein; HCLSBP1; HS1BP1; HAX-1; HSP1BP-1; HS1 binding protein; HS1-binding protein 1; HS1-associating protein X-1; SCN3; FLJ17042; FLJ18492; FLJ93803;
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GeneID
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10456
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mRNA Refseq
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NM_001018837
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Protein Refseq
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NP_001018238
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MIM
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605998
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UniProt ID
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O00165
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Chromosome Location
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1q21.3
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Function
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interleukin-1 binding; protein N-terminus binding; protein binding;
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Download Datasheet:
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