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   Your Position: Home >> PNP >> Antibody >> Mouse Anti-Human PNP Monoclonal Antibody

Mouse Anti-Human PNP Monoclonal Antibody

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Cat.No.

CAB-1048MH

Product Overview

Mouse Anti-PNP Monoclonal Antibody

Antigen Description

PNP belongs to the PNP/MTAP phosphorylase family of proteins. This protein catalyzes the reversible phosphorolysis of ribonucleosides and 2’-deoxyribonucleosides with specificity for guanine, hypoxanthine and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in T-lymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficiency cases.

specificity

Anti-PNP recognize PNP expression in HEK293 whole cell lysate.

Target

PNP

Immunogen

Purified mouse monoclonal antibody generated using E.coli expressed recombinant protein PNP (full length) as immunogen.

Host

Mouse

Isotype

Mouse IgG2a.

Species

Human

Clone

MAFB3969

conjugation

N/A

Applications

ELISA,WB

Format

Each vial contains 100 µg IgG in 100 µl of citrate-tris-HCl buffer pH7.0 with 0.02% Proclin 300.

Storage

The antibody may be stored at -20°C for one year in its original formulation. Additionally, antibody may be stored at 2°C to 8°C for up to 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles of the diluted antibody.

Antigen Gene Information

Gene Name

PNP purine nucleoside phosphorylase [ Homo sapiens ]

Official Symbol

PNP

Synonyms

PNP; purine nucleoside phosphorylase; NP, nucleoside phosphorylase; PUNP; inosine phosphorylase; purine-nucleoside:orthophosphate ribosyltransferase; NP; PRO1837; FLJ94043; FLJ97288; FLJ97312; MGC117396; MGC125915; MGC125916;

GeneID

4860

mRNA Refseq

NM_000270

Protein Refseq

NP_000261

MIM

164050

UniProt ID

P00491

Chromosome Location

14q11.2

Pathway

Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Nicotinate and nicotinamide metabolism, organism-specific biosystem; Nicotinate and nicotinamide metabolism, conserved biosystem; Purine catabolism, organism-specific biosystem; Purine metabolism, organism-specific biosystem;

Function

drug binding; nucleoside binding; phosphate ion binding; purine base binding; purine-nucleoside phosphorylase activity; purine-nucleoside phosphorylase activity;




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