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Cat.No.
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CAB-3671MH
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Product Overview
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Mouse Anti-ITGA5 Monoclonal Antibody
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Antigen Description
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The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. Integrin alpha 5 is a heterodimer that associates noncovalently with CD29/integrin beta 1 subunit to form the alpha-5-beta-1 very late antigen (VLA-5) complex. VLA-5 is a fibronectin receptor that is expressed on thymocytes, T-cells, monocytes and platelets. It is also found on very early B-cells and activated B-cells. VLA-5-mediated binding to fibronectin sends a costimulatory signal to T-cells and enhances Fc-gamma-R- and complement receptor-mediated phago-cytosis. It is also involved in monocyte migration into extracellular tissues.
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Target
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ITGA5
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Immunogen
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Purified recombinant fragment of human ITGA5 expressed in E. Coli.
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Host
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Mouse
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Isotype
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Mouse IgG2a
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Species
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Human
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Clone
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MAAG1118
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conjugation
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N/A
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Applications
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ELISA,WB,Flow Cyt
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Format
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Purified recombinant fragment of human ITGA5 expressed in E. Coli.
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Storage
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ITGA5 Antibody can be stored at 4°C, for long term storage, store at -20°C.
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Antigen Gene Information
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Gene Name
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ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [ Homo sapiens ]
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Official Symbol
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ITGA5
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Synonyms
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ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); FNRA; integrin alpha-5; CD49e; VLA-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; very late activation protein 5, alpha subunit; VLA5A;
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GeneID
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3678
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mRNA Refseq
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NM_002205
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Protein Refseq
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NP_002196
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MIM
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135620
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UniProt ID
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P08648
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Chromosome Location
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12q11-q13
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Pathway
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Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem;
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Function
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integrin binding; platelet-derived growth factor receptor binding; protein binding; receptor activity; vascular endothelial growth factor receptor 2 binding;
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