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Recombinant Mouse Grem2, His-tagged

Cat.No. : Grem2-7387M
Product Overview : A DNA sequence encoding the mouse GREM1(Met1-Asp184) was expressed in Baculovirus, with a His tag at the C-terminus.
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Description : GREM1 is a member of the DAN family. It contains 1 CTCK (C-terminal cystine knot-like) domain and is highly expressed in small intestine, fetal brain and colon. As a cytokine, GREM1 may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner and down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis. GREM1 also is an inhibitor in the TGF beta signaling pathway. It inhibits BMP-2, -4, and -7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development.
Source : Baculovirus
Species : Mouse
Tag : His
Predicted N Terminal : Lys 25
Form : Lyophilized from a 0.2μM filtered solution of 20mM Tris, 500mM NaCl, pH7.4,10% gly,0.5mM EDTA, 3mM DTT. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
Molecular Mass : The recombinant protein consists of 171 amino acids and has a calculated molecular mass of 19.7 kDa, migrates as an approximately 25 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : 1.0 eu/μg of the protein as determined by the lal
Purity : >97 % as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70℃
Storage : Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : Grem2 gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis) [ Mus musculus ]
Official Symbol : Grem2
Synonyms : GREM2; gremlin 2 homolog, cysteine knot superfamily (Xenopus laevis); gremlin-2; Gremlin1; protein related to DAN and cerberus; cysteine knot superfamily 1, BMP antagonist 2; Prdc; Gremlin2;
Gene ID : 23893
mRNA Refseq : NM_011825
Protein Refseq : NP_035955
Pathway : Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem;
Function : cytokine activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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