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Recombinant Human IL2RG protein, Fc-tagged

Cat.No. : IL2RG-7289H
Product Overview : Recombinant Human IL2RG (Leu23-Asn254) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex.
Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).
Source : HEK293
Species : Human
Tag : human IgG1 Fc
Predicted N Terminal : Leu23
Form : Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 53.5 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Leu23-Asn254
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >98% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL2RG
Official Symbol : IL2RG
Synonyms : IL2RG; interleukin 2 receptor, gamma; CIDX, combined immunodeficiency, X linked, IMD4, SCIDX1, severe combined immunodeficiency; cytokine receptor common subunit gamma; CD132; gammaC; gamma(c); CD132 antigen; common gamma-chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; severe combined immunodeficiency; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; interleukin-2 receptor subunit gamma; P64; CIDX; IMD4; SCIDX; IL-2RG; SCIDX1
Gene ID : 3561
mRNA Refseq : NM_000206
Protein Refseq : NP_000197
MIM : 308380
UniProt ID : P31785

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there any side effects of using this protein? 12/23/2022

The use of IL2RG may cause chest tightness, skin itching, allergies and other side effects, you need to contact the doctor for timely treatment.

What is the dosage and use method of IL2RG? 11/03/2022

The dosage and use method of IL2RG need to be determined according to the condition and individual situation, and need to be prescribed by a clinician.

Does IL2RG have a role and what is the mechanism? 11/28/2021

Enhances the immunity of the human immune system by increasing the number and improving the function of immune cells in the body.

Which diseases is IL2RG used to treat? 06/22/2021

IL2RG is mainly used in the treatment of immune deficiency diseases, such as systemic eosinophilic granulomatosis, X-linked immunodeficiency disease, etc.

What measures can be taken to mitigate the possible risks of IL2RG? 06/15/2021

In view of possible risks, the use of IL2RG should be strictly in accordance with the doctor's advice, and avoid changing the dosage and frequency of medication.

What are the pharmacological characteristics of IL2RG? 08/14/2019

IL2RG pharmacological features are contained in vivo to enhance the immunity of the human immune system by increasing the number of immune cells and improving their function.

Customer Reviews (3)

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Reviews
10/13/2022

    Solubility is very good and can be easily dissolved in various buffers.

    05/13/2022

      Quality I use is very good and I have recommended this product to my colleagues and friends.

      05/16/2021

        The anti-pollution ability is very strong, not easy to be polluted.

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