Recombinant Human IL2RG protein, Fc-tagged
Cat.No. : | IL2RG-7289H |
Product Overview : | Recombinant Human IL2RG (Leu23-Asn254) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
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Description : | IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID). |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Predicted N Terminal : | Leu23 |
Form : | Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 53.5 kDa. The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Leu23-Asn254 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >98% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | IL2RG |
Official Symbol : | IL2RG |
Synonyms : | IL2RG; interleukin 2 receptor, gamma; CIDX, combined immunodeficiency, X linked, IMD4, SCIDX1, severe combined immunodeficiency; cytokine receptor common subunit gamma; CD132; gammaC; gamma(c); CD132 antigen; common gamma-chain; IL-2R subunit gamma; IL-2 receptor subunit gamma; severe combined immunodeficiency; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; interleukin-2 receptor subunit gamma; P64; CIDX; IMD4; SCIDX; IL-2RG; SCIDX1 |
Gene ID : | 3561 |
mRNA Refseq : | NM_000206 |
Protein Refseq : | NP_000197 |
MIM : | 308380 |
UniProt ID : | P31785 |
Products Types
◆ Recombinant Protein | ||
IL2RG-1356M | Recombinant Mouse IL2RG protein(Met1-Ala263), hFc-tagged | +Inquiry |
IL2RG-2070R | Recombinant Rhesus Macaque IL2RG Protein, His (Fc)-Avi-tagged | +Inquiry |
IL2RG-14197H | Recombinant Human IL2RG Protein, GST-tagged | +Inquiry |
IL2RG-323H | Recombinant Human IL2RG Protein, Fc-tagged | +Inquiry |
Il2rg-4005M | Recombinant Mouse Il2rg protein(Met1-Ala263), His-tagged | +Inquiry |
◆ Lysates | ||
IL2RG-502HCL | Recombinant Human IL2RG cell lysate | +Inquiry |
IL2RG-2908MCL | Recombinant Mouse IL2RG cell lysate | +Inquiry |
IL2RG-1476RCL | Recombinant Rat IL2RG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe use of IL2RG may cause chest tightness, skin itching, allergies and other side effects, you need to contact the doctor for timely treatment.
The dosage and use method of IL2RG need to be determined according to the condition and individual situation, and need to be prescribed by a clinician.
Enhances the immunity of the human immune system by increasing the number and improving the function of immune cells in the body.
IL2RG is mainly used in the treatment of immune deficiency diseases, such as systemic eosinophilic granulomatosis, X-linked immunodeficiency disease, etc.
In view of possible risks, the use of IL2RG should be strictly in accordance with the doctor's advice, and avoid changing the dosage and frequency of medication.
IL2RG pharmacological features are contained in vivo to enhance the immunity of the human immune system by increasing the number of immune cells and improving their function.
Customer Reviews (3)
Write a reviewSolubility is very good and can be easily dissolved in various buffers.
Quality I use is very good and I have recommended this product to my colleagues and friends.
The anti-pollution ability is very strong, not easy to be polluted.
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