Recombinant Human TLR4, His tagged
Cat.No. : | TLR4-7275H |
Product Overview : | Recombinant Human TLR4 (O00206-1) (Met 1- Lys631), fused with a C-terminal polyhistidine tag, was produced in Baculovirus-Insect cells. |
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Source : | Insect Cells |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile PBS, pH 7.4 |
Molecular Mass : | The secreted recombinant human TLR4 consists of 619 amino acids and predicts a molecular mass of 70.5 KDa. The apparent molecular mass of the protein is approximately 68 Kda in SDS-PAGE under reducing conditions due to glycosylation. |
Protein Length : | Met1-Lys631 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 87 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | TLR4 toll-like receptor 4 [ Homo sapiens ] |
Official Symbol : | TLR4 |
Synonyms : | TLR4; toll-like receptor 4; CD284; hToll; TLR 4; homolog of Drosophila toll; TOLL; TLR-4; ARMD10; |
Gene ID : | 7099 |
mRNA Refseq : | NM_003266 |
Protein Refseq : | NP_003257 |
UniProt ID : | O00206 |
Products Types
◆ Recombinant Protein | ||
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TLR4-2205H | Recombinant Human TLR4 Protein, His (Fc)-Avi-tagged | +Inquiry |
TLR4-4547R | Recombinant Rhesus Macaque TLR4 Protein, His (Fc)-Avi-tagged | +Inquiry |
TLR4-421G | Recombinant Goat TLR4 Protein, His-tagged | +Inquiry |
TLR4-5741R | Recombinant Rat TLR4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TLR4-402HCL | Recombinant Human TLR4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTLR4 signaling activates NF-κB, a transcription factor, promoting the expression of pro-inflammatory genes involved in immune responses.
Ligand binding induces conformational changes in TLR4, leading to the recruitment of adaptor proteins, such as MyD88, and the activation of downstream signaling cascades.
The TLR4 signaling pathway activates innate immune responses by detecting PAMPs, triggering the release of cytokines, and promoting the elimination of pathogens.
TLR4 engages in crosstalk with other PRRs, forming a network that enhances the sensitivity and specificity of the immune response to diverse pathogens.
TLR4 consists of extracellular leucine-rich repeats (LRRs) for ligand binding, a transmembrane domain, and an intracellular Toll/interleukin-1 receptor (TIR) domain for signaling.
Customer Reviews (3)
Write a reviewPrecision in every experiment—this product is a game-changer for us.
Timely delivery is key, and this product arrived on schedule.
Exceptional customer service—knowledgeable staff guided us through the selection process.
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