Mouse Anti-VCAM1 Monoclonal Antibody

• Cat.No.: DMABT-H18424
• Product Overview: Mouse Anti-VCAM1 Monoclonal Antibody

Specification

• Antigen Description: CD106 is a 110 kD single chain type I glycoprotein also known as VCAM-1 and INCAM-110. It is expressed predominantly on activated vascular endothelium but has also been identified on follicular and interfollicular dendritic cells, some macrophages, bone marrow stromal cells, and non-vascular cell populations within joints, kidney, muscle, heart, placenta, and brain. Expression on endothelial cells as well as many other cells is induced by inflammatory stimuli and cytokines. Activated endothelial cells can release soluble forms of CD106 which can be detected in the blood. CD106 binds the integrins CD49d/CD29 (VLA-4) and alpha 4 beta 7 that contribute to leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation.
• Target: VCAM1
• Host: Mouse
• Isotype: IgG1, kappa
• species: Human
• Clone: TUB
• Conjugation: Biotin
• Applications: Flow Cyt
• Preparation: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
• Usage recommendation: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ≤0.5 μg per million cells in 100 μl volume. It is recommended that the reagent be titrated for optimal performance for each application.
• Concentration: 0.5 mg/ml
• Storage: The antibody solution should be stored undiluted at 4 °C.Do not freeze.
• Size: 25 μg;100 μg

Gene Information

• Gene Name: VCAM1 vascular cell adhesion molecule2[ Homo sapiens ]
• Official Symbol: VCAM1
• Synonyms: VCAM1; vascular cell adhesion molecule 1; vascular cell adhesion protein 1; CD106; CD106 antigen; INCAM-100; MGC99561; DKFZp779G2333
• Gene ID: 7412
• mRNA Refseq: NM_001078
• Protein Refseq: NP_001069
• MIM: 192225
• UniProt ID: P19320
• Chromosome Location: 1p32-p31
• Pathway: Adaptive Immune System, organism-specific biosystem; African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Cellular roles of Anthrax toxin, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem
• Function: cell adhesion molecule binding; cell adhesion molecule binding; integrin binding