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Mouse Anti-TSLP Monoclonal Antibody

Cat.No. : DMABT-H19273
Product Overview : Mouse Anti-TSLP Monoclonal Antibody
  • Specification
  • Gene Information
  • Related Products
Antigen Description : Thymic Stromal Lymphopoietin (TSLP) is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Ralpha) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed na?ve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFalpha) while down-regulating IL-10 and IFN-gamma suggesting a role in initiating allergic inflammation. Recent studies revealed that expression of TSLP has a direct link to the pathogenesis of allergic inflammation such as atopic dermatitis and asthma via activating dendritic cells and mast cells which trigger inflammatory Th2 response characterized by high TNF-alpha and little IL-10 production.
Target : TSLP
Host : Mouse
Isotype : IgG1, kappa
species : Human
Clone : 26C22.4
Conjugation : LEAF
Applications : Neut,ELISA
Preparation : The LEAF (Low Endotoxin, Azide-Free) antibody was Purified by affinity chromatography.
Usage recommendation : Each lot of this antibody is quality control tested by ELISA assay. For use as an ELISA detection antibody, a concentration range of 0.5-2 μg/ml is recommended. To obtain a linear standard curve, serial dilutions of TSLP recombinant protein ranging from 200 to 3.1 ng/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application.
Concentration : 1.0 mg/ml
Storage : The antibody solution should be stored undiluted at 4 °C. This LEAF solution contains no preservative; handle under aseptic conditions.
Size : 50 μg;500 μg
Gene Name : TSLP thymic stromal lymphopoietin [ Homo sapiens ]
Official Symbol : TSLP
Synonyms : TSLP; thymic stromal lymphopoietin;
Gene ID : 85480
mRNA Refseq : NM_033035
Protein Refseq : NP_149024
MIM : 607003
UniProt ID : Q969D9
Chromosome Location : 5q22.1
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : cytokine activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

Ask a question
Can WDR5 play a role in non-cancerous diseases? 05/27/2022

Yes, WDR5 has been associated with neurodevelopmental disorders, suggesting a role in non-cancerous diseases as well.

How does WDR5 affect neurodevelopment? 05/08/2020

WDR5 regulates the expression of genes critical for neural development, and dysregulation can lead to developmental disorders.

Are there any clinical trials involving WDR5-targeted therapies? 01/15/2020

Yes, there are ongoing clinical trials to test the safety and efficacy of WDR5-targeted therapies in cancer patients.

Is there a connection between WDR5 and autoimmune diseases? 02/01/2018

Some studies suggest a potential link between WDR5 and autoimmune diseases, but further research is needed to confirm this association.

How can WDR5 be used as a diagnostic marker for cancer? 11/16/2016

Elevated levels of WDR5 in certain cancers can serve as a diagnostic marker when detected in patient samples.

Customer Reviews (3)

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Reviews
04/04/2019

    The TSLP protein offered by the manufacturer excels in its quality and is an excellent match for my experimental requirements.

    02/25/2019

      Their team of experts is readily available to address any queries or concerns I may have regarding the TSLP protein.

      11/22/2016

        Their team of experts is readily available to address any concerns or queries I may have regarding the TSLP protein.

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